Conferences, Lectures, & Seminars
Events for January
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BME 533 - Seminar in Biomedical Engineering
Mon, Jan 17, 2011 @ 12:30 PM - 01:50 PM
Alfred E. Mann Department of Biomedical Engineering
Conferences, Lectures, & Seminars
Talk Title: Martin Luther King Day (No Seminar)
Host: Department of Biomedical Engineering, USC
Location: Olin Hall of Engineering (OHE) - 122
Audiences: Everyone Is Invited
Contact: Mischalgrace Diasanta
This event is open to all eligible individuals. USC Viterbi operates all of its activities consistent with the University's Notice of Non-Discrimination. Eligibility is not determined based on race, sex, ethnicity, sexual orientation, or any other prohibited factor. -
USC PSOC Monthly Seminar Series
Fri, Jan 21, 2011 @ 11:30 AM - 01:00 PM
Alfred E. Mann Department of Biomedical Engineering
Conferences, Lectures, & Seminars
Speaker: Robert Getzenberg, Ph.D., Professor and Director of the James Buchanan Brady Urological Institute,
Talk Title: Cancer cell stress response and the evolution of resistance â the connection between the physical microenvironment and nuclear structure
Abstract: The ability of cancer cells to evolve resistance is one of the major limitations in the efficacy of cancer therapies today. This enhanced evolutionary capability appears to have influenced how the cancer cell responds to physical microenvironmental changes. These microenvironmental influences appear to be act, at least in part, through nuclear structural elements and DNA organization, which have been shown to be involved in the development of resistance. Additionally, the disordered nature of protein structure appears to be central to cancer cell responses to stresses. Modification of the physical microenvironment may enhance the efficacy of currently used therapeutic agents as well as open new avenues for the development of novel types of approaches.
Location: Harkness Auditorium, CSC 250, IGM Building
For additional information contact: 323-442-3849 or 323-442-2596
Biography: Robert Getzenberg, Ph.D.
Professor and Director of the James Buchanan Brady Urological Institute,
Johns Hopkins University School of Medicine
Host: Dr. Parag Mallick, Center for Applied Molecular Medicine
Audiences: Everyone Is Invited
Contact: Yvonne Suarez
This event is open to all eligible individuals. USC Viterbi operates all of its activities consistent with the University's Notice of Non-Discrimination. Eligibility is not determined based on race, sex, ethnicity, sexual orientation, or any other prohibited factor. -
BME 533 - Seminar in Biomedical Engineering
Mon, Jan 24, 2011 @ 12:30 PM - 01:50 PM
Alfred E. Mann Department of Biomedical Engineering
Conferences, Lectures, & Seminars
Speaker: Dr. Kyriacos "Kerry" Athanasiou, UC Davis
Talk Title: Toward Mending Cartilage: Is Osteoarthritis Indeed Incurable?
Abstract: Articular cartilage is arguably the tissue most pivotal for motion and overall function. This soft, white tissue that covers the ends of our long bones cannot heal by itself. Indeed, articular cartilage is notorious for its degenerative progression to osteoarthritis following an injury. The demanding biomechanical milieu of a joint, plus cartilageâs relative lack of cells and blood supply, renders this tissue almost unique in its inability to repair adequately. This presentation will describe our group's efforts toward helping joint cartilages, such as hyaline tissue, knee meniscus, and the TMJ disc, repair themselves via tissue engineering approaches. Central to our efforts is the understanding of biomechanical relationships at multiple dimensional levels. Also shown will be some of our latest results using various stem cell sources that indicate that cartilage regeneration is inexorably becoming a tractable problem.
Biography: Kyriacos A. Athanasiou, is a Distinguished Professor and the Chair of Biomedical Engineering at the University of California Davis. He obtained his PhD from Columbia University in 1989 and has been a faculty member at the University of Texas and Rice University, prior to joining Davis in 2009. He has published 225 peer-reviewed papers, four authored books, and 28 patents. He has also served as president of the Biomedical Engineering Society. He has received numerous honors, such as the Thomas Edison Award from ASME, the Presidential Award form BMES, the Marshall Urist Award from ORS, the Van C. Mow Medal from ASME, etc. He is currently the Editor-in-Chief of the Annals of Biomedical Engineering. In addition to his academic interests, he has co-founded numerous bioengineering companies which have collectively brought to the market 15 FDA-approved products.
Host: Department of Biomedical Engineering, USC
Location: Olin Hall of Engineering (OHE) - 122
Audiences: Everyone Is Invited
Contact: Mischalgrace Diasanta
This event is open to all eligible individuals. USC Viterbi operates all of its activities consistent with the University's Notice of Non-Discrimination. Eligibility is not determined based on race, sex, ethnicity, sexual orientation, or any other prohibited factor. -
BME 533 - Seminar in Biomedical Engineering
Mon, Jan 31, 2011 @ 12:30 PM - 01:50 PM
Alfred E. Mann Department of Biomedical Engineering
Conferences, Lectures, & Seminars
Speaker: Dr. George Truskey, Duke University
Talk Title: Engineering Endothelial Progenitor Cells for Vascular Repair
Series: Invited Chair Series
Abstract: Endothelial progenitor cells can be obtained from cord blood, adult blood or bone marrow and serve as a potential source of vascular endothelium for a variety of therapeutic applications. Our own work has focused upon using late outgrowth endothelial progenitor cells for a variety of applications including seeding vascular devices, preparing, tissue engineered blood vessels and repair of endothelial injury. The focus of this talk is upon the use of human endothelial cells derived from late outgrowth cord bold (hCB-ECs) to accelerate vein graft re-endothelialization, and reduce vein graft atherosclerosis.
As a principal cause of vein graft failure, endothelial injury complicates ~500,000 vein graft procedures performed annually in the US to treat atherosclerosis. Over-distension of the vein graft by arterial pressure leads to endothelial injury, which exposes the extracellular matrix to circulating blood and promotes vein graft thrombosis. Neointimal hyperplasia subsequently predisposes vein grafts to accelerated atherosclerosis, and late vein graft failure. The hCB-ECs function similarly to vascular endothelium. The hCB-ECs demonstrate smaller size, superior adhesive properties and higher 51 integrin expression levels compared with EC adhesion to SMC/extracellular matrix is significantly greater under flow conditions with hCB-ECs than with ECs derived from adult human peripheral blood EPCs. When administered intravenously, hCB-ECs enhanced vein graft re-endothelialization, and prevented thrombosis in carotid interposition vein grafts implanted in SCID mice. To better understand the adhesion process, we examined adhesion of hCB-ECs as a function of shear stress in vitro. The number of adherent cells varied with shear stress, with the maximum number of adherent cells and the shear stress at maximum adhesion depending upon fluid viscosity. A dimensional analysis indicated that adhesion was a function of the net force on the cells, the ratio of cell diffusion to sliding speed and molecular diffusivity. This work suggests that delivery conditions can be developed to maximize adhesion of EPCs for repair of damaged arteries.
Host: Department of Biomedical Engineering, USC
Location: Olin Hall of Engineering (OHE) - 122
Audiences: Everyone Is Invited
Contact: Mischalgrace Diasanta
This event is open to all eligible individuals. USC Viterbi operates all of its activities consistent with the University's Notice of Non-Discrimination. Eligibility is not determined based on race, sex, ethnicity, sexual orientation, or any other prohibited factor.
