Conferences, Lectures, & Seminars
Events for August
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Alfred E. Mann Department of Biomedical Engineering
Fri, Aug 23, 2024 @ 11:00 AM - 12:00 PM
Alfred E. Mann Department of Biomedical Engineering
Conferences, Lectures, & Seminars
Speaker: Alyssa Panitch, Ph.D., Emory University and Georgia Tech.
Talk Title: Promoting tissue healing and regeneration using proteoglycan mimetics
Abstract: Proteoglycans play an important role in extracellular matrix remodeling, homeostasis, and signaling. Due to their negatively charged glycosaminoglycan chains as well as distinct core protein structures, they interact with a variety of molecules, including matrix proteins, growth factors, cytokines and chemokines, pathogens, and enzymes. Here we focus on two bioconjugates that were designed to mimic features of existing proteoglycans. The first models the biological activity of the small leucine-rich proteoglycan, decorin. Like native decorin, our decorin mimetic plays a key role in collagen organization and wound healing. Recently, we have augmented the decorin mimetic with peptide ligands to the avb3 integrin receptor found on endothelial and endothelial progenitor cells. The avb3 ligand confers angiogenic activity to the decorin mimetic and supports wound healing in an ischemic environment in diabetic animals. The second mimetic is designed to target inflamed endothelium to restore physical barrier function of the endothelial glycocalyx. By restoring barrier function, the glycocalyx mimetic reduces intravascular thrombosis and inflammation thereby improving healing outcomes following ischemia reperfusion injury in animal models.
Biography: Dr. Panitch received bachelor’s degrees from Smith College in Biochemistry and from the University of Massachusetts-Amherst in Chemical Engineering. She completed her Ph.D. in Polymer Science and Engineering from the University of Massachusetts. After a postdoctoral fellowship at the Swiss Federal Institute of Technology (ETH) and University of Zurich. She started her first faculty position at Arizona State University in 1999 where she was awarded an NSF CAREER award. She is currently the chair of the Wallace H. Coulter Department of Biomedical Engineering at Emory University and Georgia Tech. She is a member and Fellow of the Biomedical Engineering Society, the American Institute for Medical and Biological Engineers (AIMBE)and the National Academy of Inventors. She also serves as an Editor for the Journal of Colloids and Surfaces B: Biointerfaces.
Host: Peter Wang
Location: Corwin D. Denney Research Center (DRB) - 145
Audiences: Everyone Is Invited
Contact: Carla Stanard
This event is open to all eligible individuals. USC Viterbi operates all of its activities consistent with the University's Notice of Non-Discrimination. Eligibility is not determined based on race, sex, ethnicity, sexual orientation, or any other prohibited factor. -
Alfred E. Mann Department of Biomedical Engineering
Fri, Aug 30, 2024 @ 11:00 AM - 12:00 PM
Alfred E. Mann Department of Biomedical Engineering
Conferences, Lectures, & Seminars
Speaker: Jonathan Wang, Senior Scientist II - AbbVie , Irvine , CA
Talk Title: Navigating an Early Career in Biopharmaceuticals: From Graduate Research to Industry Expertise
Abstract: In this seminar, we will explore an early-stage career journey through various facets of the biopharmaceutical industry. Starting with a brief introduction that highlights graduate work at the University of Southern California in the Chung lab, we focus on a project utilizing polymeric micelle nanoparticles for targeted drug delivery to treat polycystic kidney disease. The talk will then delve into an industrial application, looking at process development of a pipeline vaccine in late-stage clinical development. Following this, we examine the opposite end of the regulatory approval spectrum and investigate the challenges of commercial production of a viral vector biologic. The seminar will conclude with practical tips and case studies on navigating the industry, to offer valuable insights for aspiring professionals.
Biography: Dr. Jonathan Wang obtained his undergraduate degree in Mechanical Engineering from Johns Hopkins University and PhD degree in Biomedical Engineering at the University of Southern California. During his graduate studies with Professor Eun Ji Chung, he worked on developing nanoparticles for drug delivery applications such as kidney disease. During his time at USC, he was awarded the USC Best Research Assistant Award, Viterbi Undergraduate Research Mentoring Awards, and was a recipient of the Alfred E. Mann Innovation in Engineering Doctoral Fellowship. After his PhD studies, he has joined industry as Scientist at Emergent BioSolutions and MilliporeSigma, and is now a Senior Scientist II at AbbVie in Irvine, CA.
Host: Eunji Chung
Location: Ronald Tutor Hall of Engineering (RTH) - 105
Audiences: Everyone Is Invited
Contact: Carla Stanard
This event is open to all eligible individuals. USC Viterbi operates all of its activities consistent with the University's Notice of Non-Discrimination. Eligibility is not determined based on race, sex, ethnicity, sexual orientation, or any other prohibited factor.
