SUNMONTUEWEDTHUFRISAT
Events for February 29, 2016
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Spatial Light Interference Microscopy (SLIM) for Quantitative Biomedicine
Mon, Feb 29, 2016 @ 11:00 AM - 12:00 PM
Ming Hsieh Department of Electrical and Computer Engineering
Conferences, Lectures, & Seminars
Speaker: Prof. Gabriel Popescu, Department of Electrical and Computer Engineering, University of Illinois at Urbana-Champaign
Talk Title: Spatial Light Interference Microscopy (SLIM) for Quantitative Biomedicine
Series: Medical Imaging Seminar Series
Abstract: Most living cells do not absorb or scatter light significantly, i.e. they are essentially transparent, or phase objects. Phase contrast microscopy proposed by Zernike in the 1930s represents a major advance in intrinsic contrast imaging, as it reveals inner details of transparent structures without staining or tagging. While phase contrast is sensitive to minute optical path-length changes in the cell, down to the nanoscale, the information retrieved is only qualitative. Quantifying cell-induced shifts in the optical path-lengths permits nanometer scale measurements of structures and motions in a non-contact, non-invasive manner. Thus, quantitative phase imaging (QPI) has recently become an active field of study and various experimental approaches have been proposed.
Recently, we have developed Spatial Light Interference microscopy (SLIM) as a highly sensitive QPI method. Due to its nanometer pathlength sensitivity, SLIM enables interesting structure and dynamics studies over broad spatial (nanometers-centimeters) and temporal (milliseconds-weeks) scales. I will review our recent results on applying SLIM to basic cell studies, such as intracellular transport, cell growth, and single cell tomography. Recently, we have demonstrated that SLIM is a valuable tool for cancer diagnosis and prognosis in unlabeled biopsies. This capability is particularly valuable in prostate pathology.
Biography: Gabriel Popescu is an Associate Professor in Electrical and Computer Engineering, University of Illinois at Urbana-Champaign. He received the B.S. and M.S. in Physics from University of Bucharest, in 1995 and 1996, respectively, obtained his M.S. in Optics in 1999 and the Ph.D. in Optics in 2002 from the School of Optics/ CREOL (now the College of Optics and Photonics), University of Central Florida. Dr. Popescu continued his training with the G. R. Harrison Spectroscopy Laboratory at M.I.T., working as a postdoctoral associate. He joined Illinois in August 2007 where he directs the Quantitative Light Imaging Laboratory (QLI Lab) at the Beckman Institute for Advanced Science and Technology. Dr. Popescu is an Associate Editor of Optics Express and Biomedical Optics Express, and Editorial Board Member for Journal of Biomedical Optics and Scientific Reports. He authored a book, edited another book, authored 118 journal publications, 175 conference presentations, 32 patents, gave 150 invited talks. Dr. Popescu founded Phi Optics, Inc., a start-up company that commercializes quantitative phase imaging technology. He is OSA Fellow and SPIE Fellow.
Host: Professor Justin Haldar
Location: Hughes Aircraft Electrical Engineering Center (EEB) - 132
Audiences: Everyone Is Invited
Contact: Talyia Veal
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EE-EP Seminar - Hui Fang, Monday, February 29th at 2:00pm in EEB 132
Mon, Feb 29, 2016 @ 02:00 PM - 03:30 PM
Ming Hsieh Department of Electrical and Computer Engineering
Conferences, Lectures, & Seminars
Speaker: Hui Fang, University of Illinois
Talk Title: Advanced Electronic Materials for Next-Generation Biomedical Implants and Bio tools
Abstract: Innovating electronic materials and related process technologies are critical in building next generation large scale, bio-electronic interface for biomedical implants and bio-tools.
In this talk, the influence of materials and process innovation will be discussed in the context of achieving two essential properties at the bio-electronic interface, bio conformality and bio stability. First, to reconcile the mechanic properties mismatch between soft, curvilinear organ surface and conventional rigid, planar electronics, Si nanomembrane enables bio conformal electronics from top down approach and advanced micro/nano fabrication on flexible substrates. In the second part of the talk, I will discuss how to achieve long term bio-stability at the bio-electronic interface through an ultrathin hermetic thermal silicon dioxide layer from a special device fabrication process. A capacitively coupled, bio-conformal sensing electronics with over 1,000 channels demonstrate the robustness of this encapsulation strategy. Together, these results form a realistic pathway towards bio compatible, bio conformal and bio stable electronic implants, with potential for broad utility, such as brain/heart activity mapping, brain-machine interface, and pharmaceutical screening. At the end of my talk, I will show how we can leverage recent advancements in nano electronics into building next generation bio electronics and solve big problems in biology, especially in brain activity mapping.
Biography: Dr. Hui Fang received his B.S. degree (2009) from Tsinghua University, and Ph.D. degree (2014) from the University of California, Berkeley, both in Materials Science and Engineering. At Berkeley he worked under the supervision of Prof. Ali Javey. Currently Dr. Fang is a postdoctoral research associate in Professor John A. Rogers' group at the University of Illinois, Urbana Champaign. Dr. Fang's research interests include developing novel materials, devices and related process technologies for bio-integrated electronics and nano electronics, as well as exploring new materials/device physics at the nanoscale. Dr. Fang is a recipient of the 2013 Chinese Government Award for Outstanding Self-financed Students Abroad. His publication record can be found online at http://publish.illinois.edu/huifangnano/.
Location: Hughes Aircraft Electrical Engineering Center (EEB) - 132
Audiences: Everyone Is Invited
Contact: Marilyn Poplawski
