Conferences, Lectures, & Seminars
Events for November
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Mork Family Department of Chemical Engineering and Materials Science Seminar - Distinguished Lecture Series
Tue, Nov 06, 2018 @ 04:00 PM - 05:20 PM
Mork Family Department of Chemical Engineering and Materials Science
Conferences, Lectures, & Seminars
Speaker: Professor Paul Salvador, Department of Materials Science and Engineering, Carnegie Mellon University
Talk Title: Combinatorial Substrate Epitaxy and the Design of Materials
Abstract: Over the past few decades, advancement in epitaxial growth of complex oxides has been remarkable. Most of these advances have been made using a surprisingly small number of commercially available single crystal substrates (perovskite, fluorite, corundum, rock salt, etc.). If appropriate substrates were available across all structural families, we would accelerate the design and synthesis of new materials with attractive properties. I will discuss our work on an approach to solving this dilemma, called Combinatorial Substrate Epitaxy (or CSE). In CSE we use epi-polished polycrystalline ceramics as substrates and automated electron backscatter diffraction as a non-destructive local structural characterization method. We map the orientation of hundreds of substrate grains prior to growth, then map film orientations on those same grains after deposition and use in-house programs to determine the epitaxial orientation relationships (ORs) across all of orientation space (in a single experiment). Importantly, each grain in a polycrystal behaves as an individual single crystal substrate, usually exhibiting grain-over-grain epitaxial growth. A bit surprisingly, there are only a small number (one or two) of epitaxial ORs observed across orientation space, which are largely independent of the surface orientation. On substrates where competitive polymorph nucleation occurs, the winner of the competition can be rationalized using observed ORs and planar matching on low-index orientations. Because of this, we have been able to develop a computational method that guides epitaxial synthesis. Density functional theory computations are combined with continuum models of nucleation to guide the selection of thermodynamically accessible materials and polymorph directing substrates. I will use a variety of film / substrate structural pairs to make these points, including BO2, B2O3, ABO3, A2BO4, and A2B2O7. I will describe how CSE opens the door for the predictive design of materials with new properties and the synthesis pathways to make them.
Host: Dr. Jayakanth Ravichandran
Location: 200
Audiences: Everyone Is Invited
Contact: Karen Woo/Mork Family
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13th Annual Mork Family Department Student Symposium
Fri, Nov 09, 2018
Mork Family Department of Chemical Engineering and Materials Science
Conferences, Lectures, & Seminars
Location: Edward L. Doheny Jr. Memorial Library (DML) - 240
Audiences: Everyone Is Invited
Contact: Karen Woo/Mork Family
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Mork Family Department of Chemical Engineering and Materials Science Seminar - Distinguished Lecture Series
Tue, Nov 13, 2018 @ 04:00 PM - 05:20 PM
Mork Family Department of Chemical Engineering and Materials Science
Conferences, Lectures, & Seminars
Speaker: Prof. Matthew Lazzara, Departments of Chemical Engineering and Biomedical Engineering, University of Virginia
Talk Title: Applications of mechanistic and data-driven models to problems in cell signaling
Abstract: Cells are signaled to proliferate, migrate, differentiate, and die through the action of receptors, membrane-spanning proteins that translate extracellular ligand binding events into cellular decisions by initiating networks of intracellular biochemical reactions. The complexity of these problems is ideal for, and often requires, application of computational modeling approaches to interpret data, predict system performance, and generate new hypotheses. However, the specific modeling approach must be tailored to the type and scope of problem at hand. While some problems are sufficiently circumscribed for use of familiar mechanistic governing equations, others are more easily tackled by first seeking statistical inferences from large data sets for which mechanistic governing equations are unknown. This seminar will cover examples of both types of problems. In the first part of the talk, I will describe our lab s efforts to develop experimentally validated mechanistic models of the regulation of epidermal growth factor receptor (EGFR) signaling by protein tyrosine phosphatases, focusing on the coupling between receptor endocytosis and dephosphorylation and on phosphatase-mediated regulation of the persistence of EGFR-driven signaling protein complexes. In the second part of the talk, I will describe our recent efforts to apply data-driven modeling approaches for the rational design of combination therapies for pancreas and brain cancers.
Biography: Matthew Lazzara received a B.S. in Chemical Engineering (with highest honors) from the University of Florida and a Ph.D. in Chemical Engineering from the Massachusetts Institute of Technology, where he trained in the lab of William Deen. He remained at MIT for postdoctoral studies in the lab of Douglas Lauffenburger and was the recipient of an NIH Ruth L. Kirschstein National Research Service Award Postdoctoral Fellowship. Dr. Lazzara is presently Associate Professor of Chemical Engineering and holds a joint appointment in the Department of Biomedical Engineering. Work in the Lazzara Lab employs a combination of experimental and computational methods to study problems in cell signaling, the complex biochemical process cells use to make decisions. Current projects focus on the rational (model-driven) identification of combination therapies for cancer and on fundamental studies of the spatiotemporal regulation of cell signaling by phosphatases and receptor trafficking. The lab's work is funded by grants from the American Cancer Society, National Science Foundation, and National Institutes of Health. Dr. Lazzara is also the recipient of several teaching awards, including the S. Reid Warren, Jr. Award and the Outstanding Faculty Award of the AIChE Delaware Valley, and is a member of the Board of Directors of the Museum of Science and Industry in Tampa, FL.
Host: Prof. Nicholas Graham
Location: John Stauffer Science Lecture Hall (SLH) - 200
Audiences: Everyone Is Invited
Contact: Karen Woo/Mork Family