SUNMONTUEWEDTHUFRISAT
Conferences, Lectures, & Seminars
Events for September
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Alfred E. Mann Department of Biomedical Engineering
Fri, Sep 01, 2023 @ 11:00 AM - 12:00 PM
Alfred E. Mann Department of Biomedical Engineering
Conferences, Lectures, & Seminars
Speaker: Dr. Donny W. Suh, MD, University of California, Irvine, UCI
Talk Title: An Update to Biomechanical and Biochemical Principles of Retinal Hemorrhage in Abusive Head Trauma and Other forms of Trauma
Abstract: Our investigation delves into the occurrence of retinal hemorrhages (RH) in pediatric cases stemming from diverse traumatic sources, employing both animal ocular specimens and a computational ocular model. The primary focus is to discern stress distribution patterns arising from linear and angular accelerations, as well as simulate the repetitive shaking experienced by infants. Sclerotomy apertures were meticulously created in the eyes of sheep and primates to expose the retinal tissue, facilitating the measurement of requisite tension stress for retinal separation via nanofiber manipulation. Additionally, a finite element model simulating the pediatric ocular structure was utilized to anticipate tension stress levels during instances of shaking simulating abusive head trauma. Our observations demonstrated that RH can manifest at stress magnitudes akin to those observed in animal eye experimentation during episodes of multiple shaking. Particularly, angular acceleration is implicated in generating concentrated and robust stress gradients along the retinal vasculature, while linear acceleration elicits comparatively milder and more diffused stress patterns towards the posterior ocular pole. Furthermore, employing a multicenter dataset featuring RH images of varying etiologies, we developed an artificial intelligence tool capable of ascertaining the underlying cause of RH. This tool holds potential to aid clinicians in determining the etiology behind cases of RH.
Biography: DonnyW.Suh,M.D,FAAP,MBA,FACS works at the University of California, Irvine (UCI), Gavin Herbert Eye Institute and at Childrens Hospital of Orange County (CHOC). He is Professor and Chief of Pediatric Ophthalmology and Eye Mobile Program in the Department of Ophthalmology, UCI. He completed his pediatric ophthalmology and strabismus fellowship at The Wilmer Eye Institute, Johns Hopkins University School of Medicine and his ophthalmology residency at The Eye Institute, Medical College of Wisconsin. He received his medical doctorate from Baylor College of Medicine in Houston, Texas and his Bachelor of Arts in biochemistry from Rice University in Houston, Texas.
Since 2000, Dr. Suh has been a volunteer faculty of the ORBIS Global Health Programs, and has traveled to South America, Europe, Asia, and Africa to provide medical and surgical services to the underserved as well as to teach the local ophthalmologists. He is also the Chairman for Membership Committee for American Academy of Pediatrics (AAP)Ophthalmology Section and has been voted Best Doctor in America and America s Top Ophthalmologist since 2003 to present. He has been inducted to American Ophthalmological Society (AOS), which was founded in 1864, and have been voted Inventor of the Year in 2019 at University of Nebraska Medical Center. Recently, he was nominated and selected as the 2022 Bonnie Strickland Champion for Childrens Vision Award from National Center for Childrens Vision and Eye Health at Prevent Blindness. During his free time, he enjoys golf, traveling, and spending time with family.
Host: Qifa Zhou
More Info: Zoom link upon request
Location: Olin Hall of Engineering (OHE) - 136
Audiences: Everyone Is Invited
Contact: Carla Stanard
Event Link: Zoom link upon request
This event is open to all eligible individuals. USC Viterbi operates all of its activities consistent with the University's Notice of Non-Discrimination. Eligibility is not determined based on race, sex, ethnicity, sexual orientation, or any other prohibited factor. -
Alfred E.Mann Department of Biomedical Engineering - Seminar series
Fri, Sep 08, 2023 @ 11:00 AM - 12:00 PM
Alfred E. Mann Department of Biomedical Engineering
Conferences, Lectures, & Seminars
Speaker: Yu-Ping Wang, Professor of Biomedical Engineering, Computer Sciences, Neurosciences, and Biostatistics & Data Sciences at Tulane University.
Talk Title: Interpretable multimodal deep learning with application to brain imaging and genomics data fusion
Abstract: Deep network-based data fusion models have been developed to integrate complementary information from multi-modal datasets while capture their complex relationships. This is particularly useful in biomedical domain, where multi-modal data such as imaging and multi-omics are ubiquitous and the integration of these heterogenous data can lead to novel biological findings. However, deep learning models are often difficult to interpret, bringing about challenges for uncovering biological mechanisms using these models. In this work, we develop an interpretable multimodal deep learning-based fusion model to perform automated disease diagnosis and result interpretation simultaneously. We name it Grad-CAM guided convolutional collaborative learning (gCAM-CCL), which is achieved by combining intermediate feature maps with gradient-based weights in a multi-modal convolution network. The gCAM-CCL model can generate interpretable activation maps to quantify pixel-level contributions of the input fMRI imaging features. Moreover, the estimated activation maps are class-specific, which can therefore facilitate the identification of imaging biomarkers underlying different populations such as age, gender and cognitive groups. Finally, we apply and validate the gCAM-CCL model in the study of brain development with integrative analysis of multi-modal brain imaging and genomics data. We demonstrate its successful application to both the classification of cognitive function groups and the discovery of underlying genetic mechanisms.
Biography: Dr. Yu-Ping Wang received the BS degree in applied mathematics from Tianjin University, China, in 1990, and the MS degree in computational mathematics and the PhD degree in communications and electronic systems from Xi'an Jiaotong University, China, in 1993 and 1996, respectively. After his graduation, he had visiting positions at the Center for Wavelets, Approximation and Information Processing of the National University of Singapore and Washington University Medical School in St. Louis. From 2000 to 2003, he worked as a senior research engineer at Perceptive Scientific Instruments, Inc., and then Advanced Digital Imaging Research, LLC, Houston, Texas. In the fall of 2003, he returned to academia as an assistant professor of computer science and electrical engineering at the University of Missouri-Kansas City. He is currently a Professor of Biomedical Engineering, Computer Sciences, Neurosciences, and Biostatistics & Data Sciences at Tulane University. Dr. Wangs recent effort has been bridging the gap between biomedical imaging and genomics, where has over 300 peer reviewed publications. Dr. Wang is a fellow of AIMBE and has served for numerous program committees and NSF and NIH review panels. He is currently an associate editor for J. Neuroscience Methods, IEEE/ACM Trans. Computational Biology and Bioinformatics (TCBB) and IEEE Trans. Medical Imaging (TMI). More about his research can be found at his website: http://www.tulane.edu/~wyp/
Host: Qifa Zhou
More Info: zoom link available upon request
Location: Olin Hall of Engineering (OHE) - 136
Audiences: Everyone Is Invited
Contact: Carla Stanard
Event Link: zoom link available upon request
This event is open to all eligible individuals. USC Viterbi operates all of its activities consistent with the University's Notice of Non-Discrimination. Eligibility is not determined based on race, sex, ethnicity, sexual orientation, or any other prohibited factor. -
Alfred E.Mann Department of Biomedical Engineering - Seminar series
Wed, Sep 13, 2023 @ 11:00 AM - 12:00 PM
Alfred E. Mann Department of Biomedical Engineering
Conferences, Lectures, & Seminars
Speaker: Cheri X. Deng, Professor of Biomedical Engineering - University of Michigan
Talk Title: Expanding the boundaries of biomedical ultrasound: recent results in biomaterials and mechanobiology applications
Abstract: Ultrasound has a long history in medicine, prized for its non-invasive capability and unparalleled safety profile. In recent years, biomedical ultrasound has entered a renaissance, with revived interest and rapid technological advances fueled by transducer and imaging innovations alongside interdisciplinary efforts harnessing new discoveries in basic sciences. Our lab aspires to develop novel ultrasound approaches, expanding the capability and boundaries of the versatile modality through research at the intersection of acoustics, microfabrication, biomaterials, and cell biology. In this presentation, I will highlight recent results from our projects in resonant acoustic rheometry, acoustic tweezing cytometry, and acoustic patterning - with applications in tissue engineering, mechanical characterization of biomaterials and cells, coagulation assessment, mechanobiology, and stem cell differentiation. These examples illustrate our progress and future vision to expand the boundaries of biomedical ultrasound through new collaborations that leverage leading-edge innovations across disciplines.
Biography: Dr. Cheri Deng is a Professor of Biomedical Engineering and Mechanical Engineering at the University of Michigan. Her research interests include the development of innovative biomedical ultrasound technologies for applications in the areas of imaging and intervention, non-viral intracellular drug and gene delivery, stem cells differentiation, formation of organoids, tissue engineering, biomaterials, biophysics, and mechanobiology. Supported by the National Institutes of Health and National Science Foundation, her lab has worked on various projects such as sonoporation for intracellular delivery, exosomes engineering, quantitative ultrasound imaging, high intensity focused ultrasound tissue ablation, ultrasound technologies for biomaterials/tissue engineering applications, acoustic tweezing cytometry for mechanical phenotyping and stem cell differentiation, as well as contactless acoustic bio-patterning.
Dr. Deng received her BS in Physics from Nanjing University in China, and Ph.D. in Mechanical Engineering from Yale University. She was a research staff member at Riverside Research Institute in New York City before becoming an assistant professor in the Department of Biomedical Engineering at Case Western Reserve University in 2002. She joined the faculty of University of Michigan in 2007 and was promoted to full professor in 2013. She has served as a reviewer in various study sections for the National Institutes of Health as well as other national and international funding agencies. She is a Fellow of the American Institute for Medical and Biological Engineering (AIMBE). Dr. Deng is currently serving as a member of the executive committee of the College of Engineering at the University of Michigan. She has taught both undergraduate and graduate level courses in the BME department, and mentored Post Doctoral Scientists, Doctoral students, as well as undergraduate student researchers
Host: Peter Yingxiao Wang- Chair of Alfred E. Mann Department of Biomedical Engineering
More Info: zoom link available upon request
Location: Corwin D. Denney Research Center (DRB) - 145
Audiences: Everyone Is Invited
Contact: Carla Stanard
Event Link: zoom link available upon request
This event is open to all eligible individuals. USC Viterbi operates all of its activities consistent with the University's Notice of Non-Discrimination. Eligibility is not determined based on race, sex, ethnicity, sexual orientation, or any other prohibited factor. -
Alfred E.Mann Department of Biomedical Engineering - Seminar series
Fri, Sep 15, 2023 @ 11:00 AM - 12:00 PM
Alfred E. Mann Department of Biomedical Engineering
Conferences, Lectures, & Seminars
Speaker: Cristina Zavaleta, Assistant Professor of Biomedical Engineering - USC
Talk Title: "One Little Inspiration Is at the Heart of All Creation: My Academic Journey"
Abstract: Dr. Zavaleta was born and raised in a small border town in South Texas, near Mexico. She received her Bachelors degree in Nuclear Medicine at the University of Incarnate Word, a small private university in San Antonio. After graduating, she started in the Medical Physics graduate program at the University of Texas Health Science Center in San Antonio where she focused on utilizing radioactive nanoparticles for the treatment of ovarian cancer. After receiving her Ph.D., she began a postdoctoral fellowship at Stanford University under the guidance of Dr. Sanjiv Sam Gambhir, where she helped pioneer a new molecular imaging strategy that utilizes Raman nanoparticles for cancer detection. She is currently an Assistant Professor at the University of Southern California in the department of Biomedical Engineering. Her lab focuses on providing physicians with new nano-based molecular imaging tools to improve cancer detection and treatment.
Biography: Dr. Zavaleta was born and raised in a small border town in South Texas, near Mexico. She received her Bachelors degree in Nuclear Medicine at the University of Incarnate Word, a small private university in San Antonio. After graduating, she started in the Medical Physics graduate program at the University of Texas Health Science Center in San Antonio where she focused on utilizing radioactive nanoparticles for the treatment of ovarian cancer. After receiving her Ph.D., she began a postdoctoral fellowship at Stanford University under the guidance of Dr. Sanjiv Sam Gambhir, where she helped pioneer a new molecular imaging strategy that utilizes Raman nanoparticles for cancer detection. She is currently an Assistant Professor at the University of Southern California in the department of Biomedical Engineering. Her lab focuses on providing physicians with new nano-based molecular imaging tools to improve cancer detection and treatment.
Host: Megan McCain
More Info: zoom link available upon request
Location: Olin Hall of Engineering (OHE) - 136
Audiences: Everyone Is Invited
Contact: Carla Stanard
Event Link: zoom link available upon request
This event is open to all eligible individuals. USC Viterbi operates all of its activities consistent with the University's Notice of Non-Discrimination. Eligibility is not determined based on race, sex, ethnicity, sexual orientation, or any other prohibited factor. -
Alfred E.Mann Department of Biomedical Engineering - Seminar series
Fri, Sep 22, 2023 @ 11:00 AM - 12:00 PM
Alfred E. Mann Department of Biomedical Engineering
Conferences, Lectures, & Seminars
Speaker: Dominique Duncan, PhD., Assistant Professor of Neurology, BME and USC Stevens Neuroimaging and Informatics
Talk Title: Large-scale data archives and analytic tools for neurological disorders
Abstract: The Epilepsy Bioinformatics Study for Antiepileptogenic Therapy (EpiBioS4Rx) is a multi-site, international collaboration including a parallel study of humans and an animal model, collecting MRI, EEG, and blood samples. The development of epilepsy after traumatic brain injury (TBI) is a multifactorial process and crosses multiple modalities. Without a full understanding of the underlying biological effects, there are currently no cures for epilepsy. This study aims to address both issues, calling upon data generated and collected at sites spread worldwide among different laboratories, clinical sites, in different formats, and across multicenter preclinical trials. Before these data can even be analyzed, a central platform is needed to standardize these data and provide tools for searching, viewing, annotating, and analyzing them. We have built a centralized data archive that will allow the broader research community to access these shared data in addition to analytic tools to identify and validate biomarkers of epileptogenesis in imaging and electrophysiology as well as in molecular, serological, and tissue data. Besides EpiBioS4Rx, we have also developed other large-scale multimodal data archives, including the Data Archive for the BRAIN Initiative (DABI) and the COVID-19 Data Archive (COVID-ARC) to encourage collaboration and expedite research in these areas.
Biography: Dominique Duncan is an assistant professor of Neurology, Neuroscience, and Biomedical Engineering at the USC Stevens Neuroimaging and Informatics Institute in the Laboratory of Neuro Imaging (LONI) at the University of Southern California. Dr. Duncan's background spans mathematics, engineering, and neuroscience. She received her PhD at Yale University in Electrical Engineering where she analyzed intracranial EEG data using nonlinear factor analysis to identify preseizure states of epilepsy patients. Dr. Duncan is funded through both the National Institutes of Health (NIH) and the National Science Foundation (NSF). She has built international, multidisciplinary collaborations and developed novel analytic tools to analyze multimodal data, including imaging and electrophysiology, particularly in the areas of traumatic brain injury, epilepsy, and COVID-19. By creating large-scale data repositories and linking them with analytic, visualization, and quality control tools for multimodal data, her work aims to encourage collaboration across multiple fields.
Host: Megan McCain
More Info: zoom link available upon request
Location: Olin Hall of Engineering (OHE) - 136
Audiences: Everyone Is Invited
Contact: Carla Stanard
Event Link: zoom link available upon request
This event is open to all eligible individuals. USC Viterbi operates all of its activities consistent with the University's Notice of Non-Discrimination. Eligibility is not determined based on race, sex, ethnicity, sexual orientation, or any other prohibited factor. -
Alfred E.Mann Department of Biomedical Engineering - Seminar series
Fri, Sep 29, 2023 @ 11:00 AM - 12:00 PM
Alfred E. Mann Department of Biomedical Engineering
Conferences, Lectures, & Seminars
Speaker: Xiling Shen, Adjunct Professor, Department of Pathology, Duke University
Talk Title: Developing multi-modal platforms for next-generation precision medicine
Abstract: Bodily cells undergo transformations in space and time during development, disease progression, and therapeutic treatment. A holistic approach that combines engineering tools, patient-derived models, and analytical methods is needed to map cellular reprogramming and expose new therapeutic opportunities for precision oncology. The talk will cover our effort across the entire spectrum from bench to bedside, including miniature organoid technology to guide clinical precision- and immuno-oncology, targeting epigenetic and metabolic reprogramming of cancer metastasis, algorithms to identify cancer microbiome, neuromodulation to treat cancer cachexia, and reprogramming organogenesis to create chimeric humanized models.
Biography: Dr. Shen is currently a professor and the chief scientific officer of the Terasaki Institute for Biomedical Innovation and the founder and chief executive officer of Xilis Inc. He was formerly the Hawkins Family Associate Professor in the Department of Biomedical Engineering at Duke University and Director of the Woo Center for Big Data and Precision Health. He received his BS, MS, and PhD degrees from Stanford University and the NSF faculty career award at Cornell University. He was the steering committee chair of the NCI Patient-Derived Model of Cancer Consortium, co-chair of the NCI Tissue Engineering Consortium, and cancer track chair of Biomedical Engineering Society 2019. His lab studies precision medicine from a systems biology perspective. Areas of interests include cancer, stem cells, the gut-brain axis, and microbiome.
Host: Qifa Zhou
More Info: zoom link available upon request
Location: Olin Hall of Engineering (OHE) - 136
Audiences: Everyone Is Invited
Contact: Carla Stanard
Event Link: zoom link available upon request
This event is open to all eligible individuals. USC Viterbi operates all of its activities consistent with the University's Notice of Non-Discrimination. Eligibility is not determined based on race, sex, ethnicity, sexual orientation, or any other prohibited factor.
