Events Calendar

Alfred E. Mann Department of Biomedical Engineering

Speaker: Dr. Donny W. Suh, MD, University of California, Irvine, UCI

Talk Title: An Update to Biomechanical and Biochemical Principles of Retinal Hemorrhage in Abusive Head Trauma and Other forms of Trauma

Abstract: Our investigation delves into the occurrence of retinal hemorrhages (RH) in pediatric cases stemming from diverse traumatic sources, employing both animal ocular specimens and a computational ocular model. The primary focus is to discern stress distribution patterns arising from linear and angular accelerations, as well as simulate the repetitive shaking experienced by infants. Sclerotomy apertures were meticulously created in the eyes of sheep and primates to expose the retinal tissue, facilitating the measurement of requisite tension stress for retinal separation via nanofiber manipulation. Additionally, a finite element model simulating the pediatric ocular structure was utilized to anticipate tension stress levels during instances of shaking simulating abusive head trauma. Our observations demonstrated that RH can manifest at stress magnitudes akin to those observed in animal eye experimentation during episodes of multiple shaking. Particularly, angular acceleration is implicated in generating concentrated and robust stress gradients along the retinal vasculature, while linear acceleration elicits comparatively milder and more diffused stress patterns towards the posterior ocular pole. Furthermore, employing a multicenter dataset featuring RH images of varying etiologies, we developed an artificial intelligence tool capable of ascertaining the underlying cause of RH. This tool holds potential to aid clinicians in determining the etiology behind cases of RH.

Biography: DonnyW.Suh,M.D,FAAP,MBA,FACS works at the University of California, Irvine (UCI), Gavin Herbert Eye Institute and at Childrens Hospital of Orange County (CHOC). He is Professor and Chief of Pediatric Ophthalmology and Eye Mobile Program in the Department of Ophthalmology, UCI. He completed his pediatric ophthalmology and strabismus fellowship at The Wilmer Eye Institute, Johns Hopkins University School of Medicine and his ophthalmology residency at The Eye Institute, Medical College of Wisconsin. He received his medical doctorate from Baylor College of Medicine in Houston, Texas and his Bachelor of Arts in biochemistry from Rice University in Houston, Texas.
Since 2000, Dr. Suh has been a volunteer faculty of the ORBIS Global Health Programs, and has traveled to South America, Europe, Asia, and Africa to provide medical and surgical services to the underserved as well as to teach the local ophthalmologists. He is also the Chairman for Membership Committee for American Academy of Pediatrics (AAP)Ophthalmology Section and has been voted Best Doctor in America and America s Top Ophthalmologist since 2003 to present. He has been inducted to American Ophthalmological Society (AOS), which was founded in 1864, and have been voted Inventor of the Year in 2019 at University of Nebraska Medical Center. Recently, he was nominated and selected as the 2022 Bonnie Strickland Champion for Childrens Vision Award from National Center for Childrens Vision and Eye Health at Prevent Blindness. During his free time, he enjoys golf, traveling, and spending time with family.

Host: Qifa Zhou

More Info: Zoom link upon request

Location: Olin Hall of Engineering (OHE) - 136

Audiences: Everyone Is Invited

Contact: Carla Stanard

Event Link: Zoom link upon request