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Events for March 23, 2012
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USC Physical Sciences in Oncology Center Monthly Seminar
Fri, Mar 23, 2012 @ 11:45 AM - 01:00 PM
Alfred E. Mann Department of Biomedical Engineering
Conferences, Lectures, & Seminars
Speaker: Alexander Anderson, Ph.D, Senior Member Moffitt Cancer Center
Talk Title: How Do Interactions Modulate Heterogeneity In Cancer Progression and Drug Resistance?
Abstract: The proteasome controls the concentrations of most proteins in the cytosol and nucleus of eukaryotic cells. The degradation signal or degron that targets proteins for proteolysis has two components, a proteasome binding tag, usually a poly-ubiquitin chain, and an initiation site in the form of an unstructured region in the substrate. The two degron components can function in trans when separated onto two different polypeptide chains so that a ubiquitinated adaptor can target a binding partner for proteolysis. Surprisingly, the initiation region contributes significantly to the specificity of Ubiquitin-Proteasome System. The length, location and amino acid sequence of initiation sites all affect whether a protein can be degraded or not. We define these rules in model systems and show how they apply to natural proteins. Once degradation has initiated, the proteasome normally digests its substrates processively to avoid the formation of fragments with undesirable activities. Interestingly, there are a few instances where this processivity breaks down and the proteasome generates partially degraded proteins. The partial degradation is caused by stop signals in the substrate proteins and we propose that this mechanism can explain steps in some signaling pathways and may involved in some neurodegenerative diseases.
Biography: Co-director of the Integrated Mathematical Oncology (IMO) department and Senior member at Moffitt Cancer Center. Dr. Anderson performed his doctoral work on hybrid mathematical models of nematode movement in heterogeneous environments at the Scottish Crop Research Institute in Dundee, UK. His postdoctoral work was on hybrid models of tumor-induced angiogenesis with Prof. Mark Chaplain at Bath University, UK. He moved back to Dundee in 1996 where he worked for the next 12 years on developing mathematical models of many different aspects of tumor progression and treatment, including anti-angiogenesis, radiotherapy, tumor invasion, evolution of aggressive phenotypes and the role of the microenvironment. He is widely recognized as one of only a handful of mathematical oncologists that develop truly integrative models that directly impact upon biological experimentation. His pioneering work using evolutionary hybrid cellular automata models has led to new insights into the role of the tumor microenvironment in driving tumor progression. Due to his belief in the crucial role of mathematical models in cancer research he moved his group to the Moffitt Cancer Center in 2008 to establish the Integrated Mathematical Oncology department.
Host: Center for Applied Molecular Medicine
Location: Harkness Auditorium #250
Audiences: Everyone Is Invited
Contact: kristina gerber
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W.V.T. Rusch Engineering Honors Colloquium; One Engineer's Professional Journey, From School to Industry
Fri, Mar 23, 2012 @ 01:00 PM - 01:50 PM
USC Viterbi School of Engineering, Viterbi School of Engineering Student Affairs
Conferences, Lectures, & Seminars
Speaker: Deniz K. Armani, Senior Scientist, Glenair, Inc.
Talk Title: W.V.T. Rusch Engineering Honors Colloquium; One Engineer's Professional Journey, From School to Industry
Abstract: Dr. Deniz K. Armani, Senior Scientist at Glenair, Inc., will present "One Engineer's Professional Journey, From School to Industry" as part of the W.V.T. Rusch Engineering Honors Program.
Host: W.V.T. Rusch Engineering Honors Colloquium
More Info: http://viterbi.usc.edu/students/undergrad/honors/schedules/Location: Seeley G. Mudd Building (SGM) - 101
Audiences: Everyone Is Invited
Contact: Amanda Atkinson
Event Link: http://viterbi.usc.edu/students/undergrad/honors/schedules/
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Integrated Systems Seminar Series
Fri, Mar 23, 2012 @ 02:30 PM - 04:00 PM
Ming Hsieh Department of Electrical and Computer Engineering
Conferences, Lectures, & Seminars
Speaker: Prof. Yun Chiu , UT Dallas
Talk Title: Equalization Techniques for Nonlinear Analog Circuits
Host: Hossein Hashemi
More Information: Seminar_Speaker_Chiu_2012_3_23.pdf
Location: Hughes Aircraft Electrical Engineering Center (EEB) - 248
Audiences: Everyone Is Invited
Contact: Hossein Hashemi
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An Afro-Classical Evolution within the Revolution
Fri, Mar 23, 2012 @ 07:30 PM - 09:30 PM
USC Viterbi School of Engineering
Receptions & Special Events
Admission is free. Reservations required. RSVP at the links below beginning Wednesday, February 29, at 9 a.m.
USC Students, Staff and Faculty: To RSVP, click here http://www.usc.edu/dept/pubrel/visionsandvoices/RSVP/reserve.php?RSVPEvtCode=203
General Public: To RSVP, click here http://www.usc.edu/dept/pubrel/visionsandvoices/RSVP/reserveGeneral_Multi.php?RSVPEvtCode=203
Explore the unique contributions of African Americans to the literature of classical music, focusing on orchestral works by African American composers past and present. A discussion led by Ndugu Chancler, adjunct professor of jazz studies and popular music at USC, will feature Hansonia Caldwell, professor of music emeritus at California State University, Dominguez Hills, and Robert Watt, who served as assistant principal horn for the Los Angeles Philharmonic from 1970 through 2007. The event will also include performances of orchestral compositions by African American composers, including William Grant Still and Patrice Rushen, performed by the Inner City Youth Orchestra of Los Angeles under the leadership of Maestro Charles Dickerson.
Speaker Bios:
Hansonia Caldwell is professor of music emeritus at California State University, Dominguez Hills. She is a distinguished accompanist and church organist, and is founding conductor of the Dominguez Hills Jubilee Choir, a town-and-gown multiethnic ensemble that specializes in the performance of music from African American culture.
Ndugu Chancler is a drummer, percussionist, producer, composer, clinician and educator. As a studio musician, he has recorded with such greats as Frank Sinatra, Herbie Hancock and Michael Jackson. As a songwriter, Chancler co-wrote hits for Santana, George Duke and the Dazz Band. His production credits include Flora Purim, Bill Summers, Toki and his own solo recordings.
Charles Dickerson is founder, music director and conductor of the Inner City Youth Orchestra of Los Angeles, director of music at Rolling Hills United Methodist Church and former director of the Southeast Symphony. The Inner City Youth Orchestra made its world debut at the Walt Disney Concert Hall in 2010.
Multi-GRAMMY nominated artist Patrice Rushen is a composer, producer and international recording artist. She was the first woman to serve as musical director for the GRAMMY Awards, the first woman in 43 years to serve as head composer/musical director for the Emmy Awards and the first woman musical director of the NAACP Image Awards. A classically trained pianist, Rushen is one of the music industryâs most versatile and sought after artists.
Robert Watt served as assistant principal horn for the Los Angeles Philharmonic from 1970 through 2007. Watt has been a soloist with the Los Angeles Philharmonic, the Boston Pops Orchestra, the New Jersey Symphony and many community orchestras in the Los Angeles area.
Organized by Ndugu Chancler (Jazz Studies and Popular Music).
For further information on this event:
visionsandvoices@usc.eduLocation: George Finley Bovard Administration Building (ADM) - Bovard Auditorium
Audiences: Everyone Is Invited
Contact: Daria Yudacufski
