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Events for April 06, 2015
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CS Colloquium: Steve Checkoway (Johns Hopkins) - Revealing Reality Through Reverse Engineering
Mon, Apr 06, 2015 @ 09:45 AM - 10:50 AM
Thomas Lord Department of Computer Science
Conferences, Lectures, & Seminars
Speaker: Steve Checkoway, Johns Hopkins
Talk Title: Revealing Reality Through Reverse Engineering
Series: CS Colloquium
Abstract: Insecure computer systems in the wild can enable consequences ranging from crime to mass surveillance to (in the case of cyberphysical systems) physical destruction or even death. But how can anyone know if a particular computer system is insecure? One can rely on the representations of the system designers or manufacturers; however, the history of computers is replete with examples of claims that products are secure which are subsequently proven false. This is, in part, because computer systems tend to exhibit unanticipated, unintended, or poorly-understood behaviors that have complex interactions. As a result, the best way to learn about the security of a system is to take a detailed look at the hardware and software that comprise the system, and their interactions. In the common case where hardware designs and software source code are not available, reverse engineering the system is often the best way to derive ground-truth data on how the system functions.
In this talk, I'll describe some of my recent research where reverse engineering played a key role, covering TLS implementations with backdoors as well as cyberphysical systems. I'll also describe the scientific nature of reverse engineering as well as the positive, real-world impact reverse engineering can have on security and safety.
The lecture will be available to stream HERE.
Biography: Stephen Checkoway is an Assistant Research Professor in the Department of Computer Science at Johns Hopkins University and a member of the Johns Hopkins University Information Security Institute. Checkoway's research focuses on the security of embedded and cyberphysical systems. He has demonstrated exploitable vulnerabilities in such embedded systems as electronic voting machines, laptop webcams, automobiles, and airport scanners. He received his Ph.D. in Computer Science from the University of California, San Diego in 2012.
Host: CS Department
Webcast: https://bluejeans.com/774936978Location: Olin Hall of Engineering (OHE) - 132
WebCast Link: https://bluejeans.com/774936978
Audiences: Everyone Is Invited
Contact: Assistant to CS chair
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Seminar in Biomedical Engineering
Mon, Apr 06, 2015 @ 12:30 PM - 01:50 PM
Alfred E. Mann Department of Biomedical Engineering
Conferences, Lectures, & Seminars
Speaker: Hunghao Chu, PhD, Postdoctoral Research Fellow, MIT
Talk Title: Controlled delivery of growth factors using heparin-based coacervates
Abstract: Controlled delivery of growth factors using heparin-based coacervates
Hunghao Chu, Ph.D.
Abstract
Growth factors participating in a variety of biological processes have great potential in regenerative medicine. However, unprotected growth factors degrade quickly in the body and have little efficacy at tissue repair. Delivery of growth factors with different vehicles has been examined to prolong the half-lives of growth factors and therefore increase their therapeutic efficacy. After decades of research, controlled delivery of growth factors still faces some challenges that need to be addressed properly. In my presentation, I will introduce a heparin-based coacervate platform developed for controlled release of heparin-binding growth factors. Heparin, a highly sulfated macromolecule, is used as an anticoagulant clinically. In addition, it has high affinity to a large number of biomolecules, including many growth factors. The interaction between heparin and heparin-binding growth factors is known to adjust their conformation, protect them from proteolytic degradation and regulate their activities. Incorporation of heparin in a delivery vehicle is consequently a strategy to potentiate the bioactivity of growth factors. Different from most delivery strategies employing covalent modification to immobilize heparin, we utilize a synthetic polycation to complex with heparin and form the injectable coacervate. Our experimental finding reveals several advantages of this approach: (i) the delivery vehicle itself being biocompatible and biodegradable does not trigger local or systemic toxicity. (ii) The coacervate protects growth factors from degradation and controls their release in a steady and adjustable fashion. (iii) In a mouse study, fibroblast growth factor-2 (FGF2) delivered by the coacervate (a.k.a FGF2 coacervate) generates more blood vessels than bolus FGF2, which suggests that its bioactivity is significantly enhanced. (iv) In a mouse model mimicking human myocardial infarction, we demonstrate that FGF2 coacervate achieves better therapeutic effects than bolus FGF2 by comparison of cardiac structure, blood vessel density, inflammation, fibrosis and cardiac contractility.
Biosketch
Hunghao Chu is currently a postdoctoral associate at Massachusetts Institute of Technology and Bostonâs Childrenâs Hospital. He received his B.S. in Chemistry from National Taiwan University, M.S. in Molecular and Cell Biology from National Tsing Hua University and Ph.D. in Bioengineering from University of Pittsburgh. His research interests mainly lie in protein- and RNA-based therapeutics. During his Ph.D. study, he worked under the guidance of Prof. Yadong Wang in Biomaterials Foundry and investigated controlled delivery of growth factors in an animal model of myocardial infarction. His dissertation âA coacervate-based platform for growth factor deliveryâ led to the patented technology and several peer-reviewed publications. His research has also been featured by many prestigious awards including the first place of Randall Family Big Idea Competition and the travel scholarship from Society for Biomaterials. His postdoctoral research under the supervision of Prof. Daniel Kohane and Prof. Robert Langer focuses on a biomimetic strategy to improve efficacy of mRNA therapeutic agents.
Host: Stanley Yamashiro
Location: OHE 122
Audiences: Everyone Is Invited
Contact: Mischalgrace Diasanta
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EE-Electrophysics Seminar
Mon, Apr 06, 2015 @ 02:00 PM - 03:30 PM
Ming Hsieh Department of Electrical and Computer Engineering
Conferences, Lectures, & Seminars
Speaker: Hang-Phuc Le, Lion Semiconductor Inc., CA
Talk Title: Integrated Power Supply Design - Itâs Time to Work with the Load
Abstract: In order to meet the demand for processing performance required in electronic devices, parallelism have been used to increase throughput within a strict power constraint. As parallelism increases the number of cores integrated onto a chip, there are increasing need and benefit to utilizing an independent power supply for each core in order to optimize total chip power and circuit performance. Simply adding off-chip supplies will not only incur significant degradation of supply impedance due to split package power planes and a limited number of pins, but also additional cost due to increased motherboard size and package complexity.
To address these challenges, fully integrated power converters appeared to be the ultimate solution. I will present our design methodology and techniques for the switched-capacitor approach to achieve high power density, high efficiency and sub-ns transient response using standard CMOS processes. A new architecture of fully integrated hybrid converter will also be introduced.
At the end of the talk, I will discuss how integrated power supply can be designed to improve future system efficiency and performance in many applications ranging from building power distributions to the Internet of Things and implantable devices.
Biography: Hanh-Phuc Le is currently working as the Chief Technology Officer at Lion Semiconductor Inc., a startup that he co-founded in 2012. He received the B.S. (2003), M.S. (2006), and Ph.D (2013) degrees in Electrical Engineering from Hanoi University of Technology in Vietnam, KAIST in Korea, and UC Berkeley in California, respectively.
He has held R&D and consulting positions at the the Institute of Material Science, the Vietnam Academy of Science and Technology, JDA Tech in Korea, Sun MicroSystems, Intel and Rambus. His interests include integrated power electronics, with emphasis on high-speed switch-mode power converters, fully integrated conversion, control methodology and energy-efficient mix-signal integrated circuits.
Dr. Le received the 2013 Sevin Rosen Funds Award for Innovation, the IEEE Solid-State Circuits Society Predoctoral Achievement Award 2012-2013, and the 1st Place Award in Clean & Sustainable Energy Alternatives at the 2013 Big Ideal @ Berkeley.
Host: EE-Electrophysics
Location: Hughes Aircraft Electrical Engineering Center (EEB) - 248
Audiences: Everyone Is Invited
Contact: Marilyn Poplawski
