Events Calendar

Seminars in Biomedical Engineering

Speaker: Janet Oldak, MSc., Ph.D., Professor of Dentistry, Division of Biomedical Sciences, Center for Craniofacial Molecular Biology, USC Ostrow School of Dentistry

Talk Title: Reconstructing Dental Enamel via Amelogenin-Mediated Mineral Assembly

Abstract: Dental enamel is the hardest mineralized tissue in human body. This bioceramic is composed of elongated apatite crystals, which are bundled in organized, parallel prisms, and a hierarchical structure that ensures the unique mechanical strength and biological protection that enamel provides to the tooth. Unlike other mineralized tissues, such as bone and dentin, mature enamel is acellular and cannot regenerate itself after substantial mineral loss, which often occurs as dental caries or erosion. Biomimetic enamel reconstruction is a significant topic in material science and dentistry as a novel approach for the treatment of dental caries. Amelogenin has been proven to be a critical protein for controlling the organized growth of apatite crystals. We have developed a protocol for superficial enamel reconstruction by using a novel amelogenin-chitosan hydrogel. Compared to other conventional treatments, such as topical fluoride and mouthwash, this method not only prevents the development of dental caries but also promotes significant and durable enamel restoration. The organized enamel-like microstructure regulated by amelogenin assemblies can significantly improve the mechanical properties of etched enamel, while the dense enamel-restoration interface formed by an in situ regrowth of apatite crystals can improve the effectiveness and durability of restorations. Furthermore, chitosan hydrogel is easy to use and can suppress bacterial infection, which is the major risk factor for the occurrence of dental caries. Therefore, this biocompatible and biodegradable amelogenin-chitosan hydrogel shows promise as a biomaterial for the prevention, restoration, and treatment of defective enamel.


Host: Norberto Grzywacz

Location: Olin Hall of Engineering (OHE) - 122

Audiences: Everyone Is Invited

Contact: Mischalgrace Diasanta