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Biochemical Feedback Control Theory for Synthetic Biocircuits
Wed, Apr 01, 2015 @ 01:15 PM - 02:15 PM
Ming Hsieh Department of Electrical and Computer Engineering
Conferences, Lectures, & Seminars
Speaker: Yutaka Hori, Caltech
Talk Title: Biochemical Feedback Control Theory for Synthetic Biocircuits
Abstract: Recent technological advancements have enabled us to construct
artificial biochemical networks, or biocircuits, that produce desired
dynamic functions such as bistability, oscillations and logic gates by
assembling DNA parts. This technology allows for many potential
engineering and biomedical applications, including the production of
high-value molecules and energy, and the sensing of hazardous chemicals,
using the cellular machinery of microbes. Toward a systematic
engineering of complex biological systems, model-based biocircuit design
has been increasingly important in recent years.
Biography: In this talk, we present a novel control theoretic framework to
systematically model, analyze and design the dynamics of biochemical
circuits along with experimental results. We first propose a general
feedback model representation of nonlinear biochemical dynamics. The
proposed modeling framework narrows the class of nonlinear systems down
to the degree where it allows us to develop rigorous and systematic
theoretical tools. We provide analytic and algebraic methods for
stability analysis and oscillator synthesis using the structure of the
system. Then, the utility of the developed tools is demonstrated by
experimentally implementing biochemical oscillator circuits. Finally, we
briefly show extensions of the proposed framework and discuss future
works along with some preliminary results.
Host: Prof. Edmond Jonckheere
Location: Hughes Aircraft Electrical Engineering Center (EEB) - 132
Audiences: Everyone Is Invited
Contact: Talyia Veal
