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USC Physical Sciences in Oncology Center Seminar Series
Fri, Apr 17, 2015 @ 12:00 PM - 01:00 PM
Alfred E. Mann Department of Biomedical Engineering
Conferences, Lectures, & Seminars
Speaker: Stacey Finley, Ph.D., Assistant Professor - Biomedical Engineering
Talk Title: Computational modeling of anti-angiogenic cancer therapeutics
Abstract: Systems biology approaches, including computational models, provide a framework to test biological hypotheses and optimize effective therapies that aim to inhibit tumor vascularization and growth. I will discuss my work in developing a mechanistic, compartment model of VEGF kinetics and transport in the human body and applying the model to investigate the effects of anti-angiogenic therapies targeting VEGF and its receptors. Interestingly, the model predicts that VEGF in the tumor interstitium can increase or decrease following administration of the VEGF-targeting agent, depending on properties of the tumor microenvironment. The model is useful for understanding the dynamics of VEGF distribution in the body in response to anti-VEGF agents, generating clinically relevant predictions in the areas of drug mechanism of action, biomarker identification, and personalized medicine. I will also present recent work in studying other angiogenic factors to obtain a more comprehensive understanding of the balance of promoters and inhibitors of tumor angiogenesis.
Host: USC PSOC - Dr. Shannon Mumenthaler
More Information: USC PSOC_Monthly Seminar_FINLEY_4-17-15.pdf
Location: HSC - Harkness Auditorium, CSC-250
Audiences: Everyone Is Invited
Contact: Yvonne Suarez
