Events Calendar

USC Stem Cell Seminar: Andy Groves, Baylor College of Medicine

Speaker: Andy Groves, Professor/Baylor College of Medicine

Talk Title: Hearsay: The role of Forkhead transcription factors in ear and jaw development

Series: Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research at USC Distinguished Speakers Series

Abstract: Neural crest and craniofacial placodes develop from a region of progenitors at the border of the neural plate. A long-standing puzzle is how these progenitors respond to a small family of BMP, Wnt and FGF inducing signals to adopt often radically different fates. A growing body of work suggests that distinct sets of transcription factors help progenitor cells in the regions reinforce their own fates and repress alternatives. We have shown that a forehead transcription factor, Foxi3, is expressed very early in non-neural ectoderm that will eventually form all craniofacial placodes. We have shown that Foxi3 is directly necessary for the development of the inner ear, and indirectly necessary for the survival of neural crest progenitors that drive the formation of the first and second branchial arches. Our current evidence suggests that Foxi3 may be acting as a pioneer factor in some of these events.

Host: Neil Segil

More Info: http://stemcell.usc.edu/events/details/?event_id=916781

Webcast: keckmedia.usc.edu/stem-cell-seminar (username: stem; password: seminar)

Location: Zilkha Neurogenetic Institute (ZNI) - Herklotz Seminar Room (112)

WebCast Link: keckmedia.usc.edu/stem-cell-seminar (username: stem; password: seminar)

Audiences: Everyone Is Invited

Contact: Cristy Lytal/USC Stem Cell

Event Link: http://stemcell.usc.edu/events/details/?event_id=916781