Events Calendar

USC Stem Cell Seminar: Brigid Hogan, Duke

Speaker: Brigid Hogan, Duke

Talk Title: The life of breath: Stem cells of the adult lung

Series: Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research at USC Distinguished Speakers Series

Abstract: The lung is composed of a tree-like system of branched tubes lined by a mucociliary epithelium. These carry air into the millions of thin-walled, highly vascularized peripheral gas-exchange sacs known as alveoli. The mesenchyme of the lung also contributes important stromal components, including airway and alveolar smooth muscle, fibroblasts/lipofibroblasts and an extensive vascular network. Cell turnover in both epithelial and mesodermal compartments of the mouse lung is normally very low, but in response to specific injuries and viral and bacterial infections there is extensive proliferation and differentiation of progenitor cells in different anatomical regions. A major goal has been to use lineage tracing to identify the specific subtypes of progenitor cells that help to maintain the lung at steady state and to promote repair. This has revealed unexpected plasticity in epithelial cell fate in response to changes in their local environment. 3D organoid assays have been established to screen for small molecules and pathways regulating progenitor cell behavior. Most recently Crispr/Cas9 technology has been used to identify the function of genes implicated in epithelial cell morphogenesis and differentiation.

Host: Francesca Mariani

More Info: https://calendar.usc.edu/event/speaker_brigid_hogan_duke?utm_campaign=widget&utm_medium=widget&utm_source=USC+Event+Calendar%3A+Beta#.VvGY6HDFl04

Webcast: http://keckmedia.usc.edu/stem-cell-seminar

Location: Eli & Edythe Broad CIRM Center for Regenerative Medicine & Stem Cell Resch. (BCC) - First Floor Conference Room

WebCast Link: http://keckmedia.usc.edu/stem-cell-seminar

Audiences: Everyone Is Invited

Contact: Cristy Lytal/USC Stem Cell

Event Link: https://calendar.usc.edu/event/speaker_brigid_hogan_duke?utm_campaign=widget&utm_medium=widget&utm_source=USC+Event+Calendar%3A+Beta#.VvGY6HDFl04