Events Calendar

EE 598 Cyber-Physical Systems Seminar Series

Speaker: Krishnendu Chakrabarty, Professor, Duke University

Talk Title: Digital Microfluidic Biochips: From Manipulating Droplets to A Cyberphysical System for Quantitative Gene-Expression Analysis

Abstract: Advances in microfluidics have led to the emergence of biochips for automating laboratory procedures in molecular biology. These devices enable the precise control of nanoliter volumes of biochemical samples and reagents. As a result, non-traditional biomedical applications and markets (e.g., high-throughout DNA sequencing, portable and point-of-care clinical diagnostics, protein crystallization for drug discovery), and fundamentally new uses are opening up for ICs and systems. This lecture will first introduce electrowetting-based digital microfludic biochips and provide an overview of market drivers such as immunoassays and DNA sequencing. The audience will next learn about design automation and reconfiguration aspects of microfluidic biochips. Synthesis tools will be described to map assay protocols from the lab bench to a droplet-based microfluidic platform and generate an optimized schedule of bioassay operations, the binding of assay operations to functional units, and the layout and droplet-flow paths for the biochip. The role of the digital microfluidic platform as a "programmable and reconfigurable processor" for biochemical applications will be highlighted. The speaker will describe dynamic adaptation of bioassays through cyberphysical system integration and sensor-driven on-chip error recovery.
Finally, the speaker will highlight recent advances in utilizing cyberphysical integration for quantitative gene-expression analysis. This framework is based on a real-time resource-allocation algorithm that responds promptly to decisions about the protocol flow received from a firmware layer. Results will be presented on how this adaptive framework efficiently utilizes on-chip resources to reduce time-to-result without sacrificing the chip's lifetime.


Biography: Krishnendu Chakrabarty received the B. Tech. degree from the Indian Institute of Technology, Kharagpur, in 1990, and the M.S.E. and Ph.D. degrees from the University of Michigan, Ann Arbor, in 1992 and 1995, respectively. He is now the William H. Younger Distinguished Professor of Engineering in the Department of Electrical and Computer Engineering and Professor of Computer Science at Duke University. He also serves as Director of Graduate Studies for Electrical and Computer Engineering. Prof. Chakrabarty is a recipient of the National Science Foundation Early Faculty (CAREER) award, the Office of Naval Research Young Investigator award, the Humboldt Research Award from the Alexander von Humboldt Foundation, Germany, the IEEE Transactions on CAD Donald O. Pederson Best Paper award (2015), and 11 best paper awards at major IEEE conferences. He is also a recipient of the IEEE Computer Society Technical Achievement Award (2015) and the Distinguished Alumnus Award from the Indian Institute of Technology, Kharagpur (2014). He is a Research Ambassador of the University of Bremen, Germany. He has been a Visiting Professor at University of Tokyo, Japan (2013), a Chair Professor at Tsinghua University, China (2009-2014), and a Visiting Chair Professor at National Cheng Kung University, Taiwan (2012-2013).

Prof. Chakrabarty's current research projects include: testing and design-for-testability of integrated circuits; digital microfluidics, biochips, and cyberphysical systems; optimization of enterprise systems and smart manufacturing. He is a Fellow of ACM, a Fellow of IEEE, and a Golden Core Member of the IEEE Computer Society. He holds seven US patents, with several patents pending. He was a 2009 Invitational Fellow of the Japan Society for the Promotion of Science (JSPS). He is a recipient of the 2008 Duke University Graduate School Dean's Award for excellence in mentoring, and the 2010 Capers and Marion McDonald Award for Excellence in Mentoring and Advising, Pratt School of Engineering, Duke University. He served as a Distinguished Visitor of the IEEE Computer Society during 2005-2007 and 2010-2012, and as a Distinguished Lecturer of the IEEE Circuits and Systems Society during 2006-2007 and 2012-2013. Currently he serves as an ACM Distinguished Speaker.

Prof. Chakrabarty served as Editor-in-Chief of IEEE Design & Test of Computers (2010-2012) and ACM Journal on Emerging Technologies in Computing Systems (2010-2015). Currently he serves as the Editor-in-Chief of IEEE Transactions on VLSI Systems. He is also an Associate Editor of IEEE Transactions on Computers, IEEE Transactions on Biomedical Circuits and Systems, IEEE Transactions on Multiscale Computing Systems, and ACM Transactions on Design Automation of Electronic Systems.


Host: Paul Bogdan

Location: Hughes Aircraft Electrical Engineering Center (EEB) - 248

Audiences: Everyone Is Invited

Contact: Estela Lopez