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  • Quantitative susceptibility mapping (QSM): tissue magnetism, mathematical optimization and clinical applications

    Mon, Jan 29, 2018 @ 02:30 PM - 03:30 PM

    Ming Hsieh Department of Electrical and Computer Engineering

    Conferences, Lectures, & Seminars

    Speaker: Yi Wang, PhD, Department of Biomedical Engineering & Radiology, Cornell University

    Talk Title: Quantitative susceptibility mapping (QSM): tissue magnetism, mathematical optimization and clinical applications

    Series: Biomedical Engineering Seminar

    Abstract: Tissue magnetism refers to the electron-“proton interaction, which is long range with its effects on MRI being treated as static dephasing. In contrast, tissue relaxation refers to the proton-“proton (commonly known as spin-spin) interaction, which is short range with its effect on MRI being treated with nonequilibrium quantum statistical mechanics. The long-range magnetism implies nonlocal blooming artifacts in both T2* hypointensity and phase of MRI signal. Quantitative susceptibility mapping (QSM) is to deconvolve blooming artifacts, using the Bayesian approach to the magnetic field to susceptibility source inverse problem. QSM has become sufficiently accurate and robust for routine applications. QSM is advancing MRI of tissue magnetic susceptibility from simple qualitative detection of hypointense blooming artifacts to precise measurement of biodistributions. Tissue susceptibility contains rich functional and structural information pertinent to molecular electron cloud properties. The dominant susceptibility sources in tissue are biometals, which are vital participants in cellular functions and pathologies. QSM can be useful for diseases that involve neurodegeneration, inflammation, hemorrhage, abnormal oxygen consumption, substantial alterations in highly paramagnetic cellular iron, bone mineralization, or pathologic calcification; and for all disorders in which MRI diagnosis or surveillance requires contrast agent injection. Clinicians should consider integrating QSM into their routine imaging practices by including gradient echo sequences in all relevant MRI protocols.

    Location: Hughes Aircraft Electrical Engineering Center (EEB) - 248

    Audiences: Everyone Is Invited

    Contact: Talyia White


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