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BME seminars

Abstract: Over the past decade we have been working to develop functional and molecular imaging technologies for a variety of applications. A current focus is technologies capable of functional imaging of picometer scale vibrations in the ear. This collaboration with researchers in otolaryngology has led to several recent papers that contribute new understandings of inner ear function. These were enabled by our development of Optical Coherence Tomography (OCT) as a highly sensitive spatially resolved vibrometer. Building on this approach, we have begun to develop devices to fill unmet clinical needs for diagnosis and therapeutic guidance in humans. The first of those devices (cochleoscope) is an endoscopic OCT system designed to traverse the human ear canal and peer into the inner ear through the round window. This device would be used clinically to identify endolymphatic hydrops, anomalous vibratory response, and ischemia of the inner ear. We recently demonstrated this device in a porcine model and have IRB approval for a first-in-human trial at USC. A second device attaches to the standard operating microscopes in the hearing clinic, enabling noninvasive imaging of middle ear morphology and function. In vivo human testing of this device has shown that we can achieve a sensitivity to vibrations of of

More Information: Brian E. Applegate Flyer.pdf

Location: 145a

Audiences: Everyone Is Invited

Contact: Mischalgrace Diasanta