Events Calendar

AME Seminar

Speaker: Owen McCarty, Oregon Health & Science University

Talk Title: The Blood Microenvironment in Thrombosis and Hemostasis: The Good, Bad and the Sticky

Abstract: Hemostatic plug formation upon blood vessel breach is initiated by platelet recruitment, activation and aggregation in concert with thrombin generation and fibrin formation. However, a similar process can also lead to pathological processes including deep vein thrombosis, ischemic stroke, or myocardial infarction, among others. We have developed narrow mechanism-specific agents targeting the intrinsic pathway of coagulation and demonstrated that experimental thrombosis and platelet production in primates is interrupted by selective inhibition of activation of coagulation factor (F)XI by FXIIa. In this seminar, I will present new data on the role of the endothelium in inactivating FXI, as well as studies on whether inhibiting FXI is beneficial in a non-human primate model of sepsis. I will present our first data from our clinical trial on the safety of inhibition of FXI, and plans to test the efficacy of FXI inhibition in dialysis. The understanding of the mechanisms by which the intrinsic pathway of coagulation promotes thrombus formation may support the rationale for the development of selective, safe and effective antithrombotic strategies targeting FXI.

Owen McCarty, a native of Rochester, received his B.S. in Chemical Engineering from SUNY Buffalo, and a Ph.D. degree in Chemical Engineering from Johns Hopkins University, where his research focused on the identification and characterization of tumor cell receptors for blood platelets and leukocytes. He performed his postdoctoral research on platelet cell biology in the Pharmacology Department at the University of Oxford and University of Birmingham, UK in the group of Dr. Steve Watson. Dr. McCarty joined Oregon Health & Science University in 2005, where he holds an appointment as a Professor in the Departments of Biomedical Engineering and Cell, Developmental & Cancer Biology and the Division of Hematology & Medical Oncology in the OHSU School of Medicine. Dr. McCarty serves as the Chair of the Biomedical Engineering Department and a fellow of the American Heart Association.

Wednesday, April 10, 2019
3:30 PM
Seaver Science Library, Room 150 (SSL 150)
Refreshments will be served at 3:15 pm.

Host: AME Department

Location: Seaver Science Library (SSL) - 150

Audiences: Everyone Is Invited

Contact: Tessa Yao