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  • Mork Family Department of Chemical Engineering and Materials Science Seminar - Distinguished Lecture Series

    Tue, Oct 08, 2019 @ 04:00 PM - 05:20 PM

    Mork Family Department of Chemical Engineering and Materials Science

    Conferences, Lectures, & Seminars


    Speaker: Professor Yvonne Chen, University of California, Los Angeles

    Talk Title: Engineering Next-Generation T Cells for Cancer Immunotherapy

    Abstract: The adoptive transfer of T cells expressing chimeric antigen receptors (CARs) has demonstrated clinical efficacy in the treatment of advanced cancers, with anti-CD19 CAR-T cells achieving up to 90% complete remission among patients with relapsed B-cell malignancies. However, challenges such as antigen escape and immunosuppression limit the long-term efficacy of adoptive T-cell therapy. Here, I will discuss the development of next-generation T cells that can target multiple cancer antigens and resist immunosuppression, thereby increasing the robustness of therapeutic T cells against tumor defense mechanisms. Specifically, I will discuss the development of multi-input receptors and T cells that can interrogate intracellular antigens. I will also discuss the engineering of T cells that can effectively convert TGF-beta from a potent immunosuppressive cytokine into a T-cell stimulant. This presentation will highlight the potential of synthetic biology in generating novel mammalian cell systems with multifunctional outputs for therapeutic applications.

    Host: WIChE

    Location: John Stauffer Science Lecture Hall (SLH) - 102

    Audiences: Everyone Is Invited

    Posted By: Karen Woo/Mork Family

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