Events Calendar

AME Seminar

Speaker: Alison Marsden, Stanford

Talk Title: Patient-Specific Modeling for Virtual Treatment Planning in Pediatric Cardiology

Abstract: Cardiovascular disease is the leading cause of death worldwide, with nearly 1 in 4 deaths caused by heart disease alone. In children, congenital heart disease affects 1 in 100 infants, and is the leading cause of infant mortality in the US. Patient-specific modeling based on medical image data increasingly enables personalized medicine and individualized treatment planning in cardiovascular disease patients, providing key links between the mechanical environment and subsequent disease progression. We will discuss recent methodological advances in cardiovascular simulations, including (1) optimization and uncertainty quantification for surgical planning, and (2) a unified finite element formulation for fluid structure interaction towards fluid solid growth. Clinical application of these methods will be demonstrated in two applications: 1) a novel surgical method for stage one single ventricle palliation, and 2) virtual treatment planning in pediatric patients with peripheral pulmonary stenosis. We will also provide an overview of our open source SimVascular project, which makes our tools available to the scientific community (www.simvascular.org). Finally, we will provide an outlook on recent successes and challenges of translating modeling tools to the clinic.

Biography: Alison Marsden is an associate professor in the departments of Pediatrics, Bioengineering, and, by courtesy, Mechanical Engineering at Stanford University. She is a member of the Institute for Mathematical and Computational Engineering. From 2007-2015 she was a faculty member in Mechanical and Aerospace Engineering at UCSD. She graduated with a BSE degree in Mechanical Engineering from Princeton University in 1998, and a PhD in Mechanical Engineering from Stanford in 2005. She was a postdoctoral fellow at Stanford University in Bioengineering from 2005-07. She was the recipient of a Burroughs Wellcome Fund Career Award at the Scientific Interface in 2007, an NSF CAREER award in 2011, and was elected as a fellow of AIMBE and SIAM in 2018. She has published over 100 peer reviewed journal papers and serves on the editorial board of several journals. Her research focuses on the development of numerical methods for cardiovascular blood flow simulation and application of engineering tools to impact patient care in cardiovascular surgery and congenital heart disease.



Host: AME Department

More Info: https://ame.usc.edu/seminars/

Location: John Stauffer Science Lecture Hall (SLH) - 102

Audiences: Everyone Is Invited

Contact: Tessa Yao

Event Link: https://ame.usc.edu/seminars/