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Programming cell-fate decisions with RNA control devices

Distinguished Lecture SeriesPresentsProgramming cell-fate decisions with RNA control devices"Professor Christina D. Smolke
Stanford University
Stanford, Ca
mailto:muthu@polysci.umass.edu AbstractCellular behavior is encoded and controlled by complex genetic networks. Synthetic genetic devices that interface with native pathways can be used to change natural networks to implement new forms of control and behavior. Significant recent work on the engineering of synthetic gene networks has been limited by an inability to interface with native networks and components. To overcome these limitations, we have developed RNA control devices that process and transmit molecular signals that are received by integrated sensor domains to targeted protein level outputs, linking computation and logic to gene expression and thus cellular behavior in mammalian cells. The modularity inherent in our device design supports the rational assembly of these RNA controllers from independent components exhibiting basic functions and the extension to more sophisticated information processing schemes, highlighting the potential of synthetic biology strategies to support the rapid engineering of cellular behavior. Coupled with technologies that enable the de novo generation of new RNA sensor components, RNA devices allow researchers to construct various user-programmed information processing operations in living systems. The application of these molecular devices to developing new disease treatment strategies such as targeted molecular and cellular therapeutics will be discussed.

Location: James H. Zumberge Hall Of Science (ZHS) - 159

Audiences: Everyone Is Invited

Contact: Petra Pearce Sapir