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Multiparameter Computational Modeling of Tumor Invasion

The USC Center for Applied Molecular Medicine, as part of the Physical Sciences Oncology Center, is proud to present Dr. Vittorio Cristini, Ph.D., Professor and Director, Center for Computational Biomedicine, The University of Texas Health Science Center at Houston, M.D. Anderson Cancer Center. ABSTRACT: Clinical outcome prognostication in oncology is a guiding principle in therapeutic choice. A wealth of qualitative empirical evidence links disease progression with tumor morphology, histopathology, invasion, and associated molecular phenomena. However, the quantitative contribution of each of the known parameters in this progression remains elusive. Mathematical modeling can provide the capability to quantify the connection between variables governing growth, prognosis, and treatment outcome. By quantifying the link between the tumor boundary morphology and the invasive phenotype, this work provides a quantitative tool for the study of tumor progression and diagnostic/prognostic applications. This establishes a framework for monitoring system perturbation towards development of therapeutic strategies and correlation to clinical outcome for prognosis.

Location: Grace Ford Salvatori Hall Of Letters, Arts & Sciences (GFS) - -106 (UPC)

Audiences: Everyone Is Invited

Contact: Yvonne Suarez