Events Calendar

Epstein ISE Research Seminar

Speaker: Dr. Edwin Romeijn, Professor/Department of Industrial and Operations Engineering University of Michigan. Ann Arbor

Abstract: Traditionally, Intensity Modulated Radiation Therapy (IMRT) treatment planning has been performed in two phases: a first phase, called fluence map optimization, in which optimal beamlet intensities are determined, followed by a second, leaf sequencing, phase in which these fluence maps are decomposed into deliverable apertures and corresponding intensities. We instead consider an integrated modeling framework that is exact in the case where convex criteria are used to evaluate the quality of a treatment plan. This framework can be used to incorporate many aspects of the treatment plan that are typically dealt with in an approximate way or in a postprocessing phase. In particular, this approach lends itself very well to incorporating issues that cannot be incorporated directly in a beamlet-based fluence map optimization approach – such as transmission, the tongue-and-groove effect, and other approximations or uncertainties in the traditional dose model. In addition, beam-on-time can be incorporated as an explicit criterion or constraint. We will also discuss its promise for extensions to new treatment delivery modalities, such as Volumetric Modulated Arc Therapy (VMAT) and Image-Guided Radiation Therapy (IGRT). We discuss potential clinical applications and benefits of this modeling approach.

Biography: Edwin Romeijn received his M.S. in econometrics and Ph.D. in operations research from Erasmus University Rotterdam in The Netherlands. He joined the Department of Industrial and Operations Engineering at the University of Michigan in 2008 after being a faculty member at the Department of Decision and Information Sciences at the Rotterdam School of Management of Erasmus University Rotterdam and the Department of Industrial and Systems Engineering at the University of Florida. He has taught courses in operations research, stochastic processes, applied probability and statistics, supply chain management, and decision support systems. His research focuses on optimization theory and applications, in particular in the areas of supply chain optimization and optimization in health care. He is the author of over eighty-five peer reviewed journal publications.

Location: Hughes Aircraft Electrical Engineering Center (EEB) - Room 248

Audiences: Everyone Is Invited

Contact: Georgia Lum