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USC PSOC Seminar Series - Dr. Steven Henikoff
Fri, May 20, 2011 @ 11:45 AM - 01:00 PM
Alfred E. Mann Department of Biomedical Engineering
Conferences, Lectures, & Seminars
Speaker: Steven Henikoff, PhD, Fred Hutchinson Cancer Research Center
Talk Title: Histone Variants, Nucleosome Dynamics, and Epigenetics
Abstract: Variants of histone H3 and H2A are found in all eukaryotes and play fundamental roles in epigenetic processes. The replacement variant, H3.3, becomes enriched at actively transcribed genes and regulatory elements and provides a glimpse into nucleosome dynamics. H2A.Z is enriched around gene promoters, antagonizes DNA methylation, and is profoundly altered during oncogenic transformation. CenH3 forms centromere-specific nucleosomes that organize and maintain the kinetochore at a unique position on the chromosome. We have found that CenH3 nucleosomes are very different from bulk nucleosomes, both in histone core structure and in DNA topology, with likely implications for centromere function and inheritance.
NRT â Harlyne J. Norris Research Tower, Lower Ground Level
1450 Biggy Street, Los Angeles, CA
Host: Center for Applied Molecular Medicine. IGM, 2250 Alcazar Street, CSC-250, Los Angeles, CA. Information - contact Kristina Gerber at 323-442-3849. Pizza and beverages served for attendees at 11:45 a.m.
Location: Harlyne J. Norris Research Tower (NRT) -
Audiences: Everyone Is Invited
Contact: Yvonne Suarez
