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USC Physical Sciences in Oncology Center Monthly Seminar Series
Fri, Jul 22, 2011 @ 11:45 AM - 01:00 PM
Alfred E. Mann Department of Biomedical Engineering
Conferences, Lectures, & Seminars
Speaker: Matteo Pellegrini Ph.D, UCLA Department of Molecular, Cell and Developmental Biology
Talk Title: Transgenerational Inheritance of DNA Methylation
Abstract: DNA Methylation is thought to play an important role in the regulation of gene expression and cellular differentiation. Recently it has become possible to profile the entire DNA methylome using bisulfite sequencing coupled with next generation sequencers. Using these approaches several studies have identified regions that are differentially methylated across different cell types. However, the degree to which DNA methylation is heritable across generation remains an open question. We are currently investigating how patterns of DNA methylation are preserved in parental and F1 crosses in both pants and mammals. We are also investigating the role that diet plays on transgenerational DNA methylation patterns in mice. A fuller understanding of these effects will allow us to more completely understand how the effects of environmental changes can be propagated across generations.
CSC Building 2nd Floor - Harkness Auditorium
Host: Center for Applied Molecular Medicine. IGM, 2250 Alcazar Street, CSC-250, Los Angeles, CA. Information - contact Kristina Gerber at 323-442-3849. Pizza and beverages served for attendees at 11:45 a.m.
Location: Clinical Science Center (CSC) - Harkness Auditorium - IGM
Audiences: Everyone Is Invited
Contact: Kristina Gerber
