Events Calendar

USC Physical Sciences in Oncology Center Monthly Seminar Series

Speaker: Claudia Fischbach, Ph.D., Assistant Professor, Department of Biomedical Engineering, Cornell University

Talk Title: Engineered Microenvironments to Study Tumor Angiogenesis

Abstract: Tumor angiogenesis is regulated by dynamic interactions between tumor and stromal cells, which evolve in response to dysregulated microenvironmental conditions. Compared to normal tissues, tumors are characterized by aberrant 3-D cell-cell and cell-extracellular matrix interactions as well as variations in tissue oxygen tension. However, the biological and physical phenomena by which these parameters modulate the heterogeneous pro-angiogenic capability of tumor and stromal cells remain unclear due in part to the lack of appropriate model systems. This talk will highlight the importance of integrated tissue engineering, cancer biology, and computational modeling approaches to investigate the molecular, cellular, and tissue level responses underlying tumor angiogenesis. A particular emphasis will be placed on evaluating the regulatory roles of tissue oxygen level and physiochemical properties of the extracellular matrix using microfabricated 3-D culture models and advanced imaging approaches, respectively. These studies advance our understanding of tumor heterogeneity and may inform the design of anti-angiogenic therapies for more efficacious therapies for cancer patients.

CSC Building 2nd Floor - Harkness Auditorium


Host: Center for Applied Molecular Medicine. IGM, 2250 Alcazar Street, CSC-250, Los Angeles, CA. Information - contact Kristina Gerber at 323-442-3849. Pizza and beverages served for attendees at 11:45 a.m

Location: Clinical Science Center (CSC) - Harkness Auditorium

Audiences: Everyone Is Invited

Contact: Kristina Gerber