Events Calendar

USC Physical Sciences in Oncology Center Monthly Seminar Series

Speaker: Mitch Magee, Ph.D., Assistant Research Professor, Biodesign Institute, ASU

Talk Title: High Throughput Functional Proteomics for Investigations of Host Response to Lymphoma

Abstract: Functional proteomics combines derivation of molecular biology tools for high-throughput cloning in combination with expression strategies for functional analyses of proteins. Our strategy focuses on the use of Nucleic Acid Programmable Protein Arrays (NAPPA) for displaying high content proteins for down-stream studies. We are utilizing NAPPA in two key strategies as it applies to the USC - Physical Sciences in Oncology Center program. We are utilizing NAPPA to create a 10,000 member set of protein production slides and utilize these proteins to characterize autoantibody production during lymphoma development in an animal model. We have also adapted NAPPA for protein-protein interaction kinetic analyses to enable relative affinity measures of proteins within the B-Cell signaling pathway. The ultimate goal is to work with mathematical modelers to outilze these measures for developing a Virtual Cancer Model to predict the host reactivitiy and response to therapy.

Biography: About the USC Physical Sciences in Oncology Center Monthly Seminar Series

USC was selected to establish a $16 million cancer research center as part of a new strategy against the disease by the U.S. National Institutes of Health and its National Cancer Institute. The new center is one of 12 in the nation to receive the designation. During the five-year initiative, the Physical Sciences-Oncology Centers will take new, nontraditional approaches to cancer research by studying the physical laws and principles of cancer; evolution and the evolutionary theory of cancer; information coding, decoding, transfer and translation in cancer; and ways to de-convolute cancer’s complexity. As part of the outreach component of this grant, the Center for Applied Molecular Medicine is hosting a monthly seminar series

Host: Center for Applied Molecular Medicine. IGM, 2250 Alcazar Street, CSC-250, Los Angeles, Ca. Information - contact Kristina Gerber at 323-442-3849. Pizza and beverages served for attendees at 11:45 a.m.

Location: Clinical Science Center (CSC) - Harkness Auditorium

Audiences: Everyone Is Invited

Contact: Kristina Gerber