Events Calendar

Frequency-selective Methods for Hyperpolarized 13C Cardiac Magnetic Resonance Imaging

Speaker: Angus Z. Lau, Department of Medical Biophysics, University of Toronto

Talk Title: Frequency-selective Methods for Hyperpolarized 13C Cardiac Magnetic Resonance Imaging

Abstract: Abstract: Heart failure is a complex clinical syndrome in which the heart cannot pump sufficient blood and nutrients to the organs in the body. Increasingly, alterations in cardiac energetics are being implicated as playing an important role in the pathogenesis of heart failure. An understanding of specific metabolic switches which occur during the development of heart failure in patients would be greatly beneficial as a new diagnostic method and for the development of new therapies for patients with failing hearts.

Spatially resolved images of hyperpolarized 13C substrates and their downstream products can provide insight into real-time metabolic processes occurring in vivo, within minutes of injection of a pre-polarized 13C-labeled substrate. Conventional 3D spectroscopic acquisitions require in excess of 100 excitations, making it challenging to acquire full cardiac and respiratory-gated, whole-heart metabolic volumes. In this talk, I will describe progress towards robust and reproducible measurements of cardiac metabolism using frequency-selective methods in hyperpolarized carbon-13 MRI.


Host: Prof. Krishna Nayak

Location: Hughes Aircraft Electrical Engineering Center (EEB) - 248

Audiences: Everyone Is Invited

Contact: Talyia Veal