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AME Seminar
Wed, Apr 16, 2025 @ 03:30 PM - 04:30 PM
Aerospace and Mechanical Engineering
Conferences, Lectures, & Seminars
Speaker: Boyce Eugene Griffith, University of North Carolina
Talk Title: Computational Cardiac Fluid Dynamics In Vitro and In Vivo
Abstract: Cardiac fluid dynamics fundamentally involves interactions between complex blood flows and the structural deformations of the muscular heart walls and the thin, flexible valve leaflets. This talk will provide an overview of modern numerical methods for treating such fluid-structure interactions and detail some of their applications to cardiac fluid dynamics. I will initially focus on models of an in vitro pulse-duplicator system that is commonly used in the development and regulation of prosthetic heart valves. These models enable detailed comparisons between experimental data and computational model predictions but use highly simplified descriptions of cardiac anatomy and physiology. I will describe experimental and computational investigations on determinants of prosthetic heart valve dynamics using this platform. I will also present recent in vitro models, including a patient-specific model of transcatheter aortic valve replacement and a new comprehensive model of the human heart. This heart model includes fully three-dimensional descriptions of all major cardiac structures along with biomechanics models that are parameterized using experimental tensile test data obtained exclusively from human tissue specimens. Simulation results demonstrate that the model generates physiological stroke volumes, pressure-volume loops, and valvular pressure-flow relationships, thereby illustrating is its potential for predicting cardiac function in both health and disease. I will end the talk by describing extensions of this model to incorporate a comprehensive description of cardiac electrophysiology and electro-mechanical coupling.
Biography: Boyce Griffith is a Professor of Mathematics at the University of North Carolina at Chapel Hill (UNC-Chapel Hill) with a joint appointment in the Lampe Joint Department of Biomedical Engineering at UNC-Chapel Hill and North Carolina State University. He received a PhD in Mathematics from New York University's Courant Institute of Mathematical Sciences in 2005. His interests include mathematical modeling and computer simulation of cardiac mechanics, fluid dynamics, and electrophysiology, with a focus on the fluid dynamics of native and prosthetic heart valves.
Host: AME Department
More Info: https://ame.usc.edu/seminars/
Location: James H. Zumberge Hall Of Science (ZHS) - 252
Audiences: Everyone Is Invited
Contact: Tessa Yao
Event Link: https://ame.usc.edu/seminars/
This event is open to all eligible individuals. USC Viterbi operates all of its activities consistent with the University's Notice of Non-Discrimination. Eligibility is not determined based on race, sex, ethnicity, sexual orientation, or any other prohibited factor.
