Events Calendar

Alfred E.Mann Department of Biomedical Engineering - Seminar series

Speaker: Amy Herr, Ph.D. , Professor of Bioengineering, and a Chan Zuckerberg Biohub Investigator University of California, Berkeley

Talk Title: “Design of microanalytical tools to understand single-cell biology

Abstract: My lab is interested in design of microanalytical tools to address cellular-resolution questions thatare difficult (or impossible) to answer with existing approaches. Our research spans from questionsin cancer biology and developmental biology to symbiotic cellular systems and cell biology. Wetackle questions where protein expression, state, and function play important biological roles, andwe are particularly interested in questions where proteoforms (e.g., protein isoforms) are keymolecular players. In this talk, I will focus on two areas where precision microfluidic tools formolecular and cellular measurements are accelerating biological understanding. First, single-cellgenomics and transcriptomics tools have radically changed the biological sciences andbiomedicine. Further, microfluidic tools have radically expanded the capabilities of thesesequencing tools (e.g., sequencing flow cells and droplet systems). Our aim is to bring the powerof single-cell understanding to proteomics (targeted & discovery) by leveraging the precision ofmicrofluidic design. Second, I will describe recent research from my lab that physically linkstogether multiple, independent measurement modalities in a ‘single-cell, same-cell’ paradigm. Ourlong-term vision is to create tools that allow researchers to ex-post query a unique originating cellfor protein-level information, as informed by a priori sequencing-based discovery. Taken together,we strive to introduce tools uniquely equipped to measure both cellular and molecularheterogeneity as a means to more comprehensively understand cellular form and function.

Biography: Dr. Herr is Professor of Bioengineering at the University of California, Berkeley and a ChanZuckerberg Biohub Investigator. She received a BS degree in Engineering & Applied Science fromthe California Institute of Technology and MS and PhD degrees in Mechanical Engineering fromStanford University. Professor Herr is an elected Fellow of the American Institute of Medical andBiological Engineering (AIMBE) and an elected member of the National Academy of Inventors. Herresearch interests include bioinstrumentation innovation to advance quantitation in the biosciences& biomedicine, in particular the study and application of electrokinetic phenomena in single-celland sub-cellular analyses. She has been recognized as a: Sciex Microscale SeparationsInnovation Medalist (2018), Visionary Awardee by the City of Berkeley (2017; one of three), ChanZuckerberg Biohub Investigator (2017-2022), 2016 Mid-Career Achievement Award from theAmerican Electrophoresis Society (AES), 2015 Georges Guiochon Faculty Fellow from HPLC(inaugural), 2012 Young Innovator Award from Analytical Chemistry/CBMS, 2011 NSF CAREERaward, 2010 NIH New Innovator Award, 2010 Alfred P. Sloan Research Fellowship in chemistry,2010 New Investigator Award in Analytical Chemistry from Eli Lilly & Co., 2009 Defense AdvancedResearch Projects Agency (DARPA) Young Faculty Award, 2009 Hellman Family Faculty FundAward from UC Berkeley.

Host: Maral Mousavi

Location: Ronald Tutor Hall of Engineering (RTH) - 109

Audiences: Everyone Is Invited

Contact: Carla Stanard

This event is open to all eligible individuals. USC Viterbi operates all of its activities consistent with the University's Notice of Non-Discrimination. Eligibility is not determined based on race, sex, ethnicity, sexual orientation, or any other prohibited factor.

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