Events Calendar

Aerospace and Mechanical Engineering Candidate Series

Speaker: Janna Nawroth, Postdoctoral Technology Development Fellow at the Wyss Institute for Biologically Inspired Engineering at Harvard University, Cambridge, MA

Talk Title: Multiscale Fluid Sensing and Transport in Biological and Engineered Systems

Abstract: Deformable substrates mediate fluid transport and sensing in many biological systems (e.g., marine animals, inner organs), as well as in some engineered systems (soft microfluidics, soft robots). The latter, however, employ only a fraction of the multitude of mechanisms found in nature. Partly, this reflects the difficulty of isolating straightforward structure-function relationships in multiscale biological tissues that could be translated to engineered materials. The same difficulty has impeded the development of in vitro assays and diagnostics tools for (fluid-) mechanically mediated diseases, such as polycystic kidney syndrome, hearing loss, osteoporosis, and cardiomyopathy. I approach this challenge by studying native and engineered tissues specialized for a particular transport function, which enables me to isolate, quantify, and reverse-engineer selected structure-function relationships. For this, I combine the powers of flow visualization, microfluidic platforms, tissue engineering, and computational studies. Here, I will present major results and goals of my research including (1), quantifying the structure-function relationships of muscle and cilia in health and disease, with applications in biophysical studies, diagnostics, and drug discovery ("organs-on-chips"); (2), designing and building cell-based microfluidic analyzers and processors; and (3), developing biologically-inspired multiscale surfaces for controlling dynamic fluid-structure interactions, such as biofilm formation.

Biography: Janna C. Nawroth is a postdoctoral Technology Development Fellow at the Wyss Institute for Biologically Inspired Engineering at Harvard University. She attended Heidelberg University, Germany, where she received her B.S. (2004) and M.S. (2007) in Biotechnology. For her master thesis, Nawroth joined Yale University as a research associate in computational biology with Professor Gordon Shepherd. After Yale, Nawroth attended the California Institute of Technology as a Moore Fellow and obtained her Ph.D. (2012) in Biology. Nawroth's Ph.D. research, with Professor John Dabiri, received Caltech's award for the Best Thesis in Nanotechnology and involved the study and design of muscle-powered pumps to manage microfluidic propulsion and particle transport. After her Ph.D., Nawroth spent a year as a Caltech Postdoctoral Fellow in Aeronautics collaborating with Professors John Dabiri, Eva Kanso (USC), Scott Fraser (USC), and Margaret-McFall-Ngai (U Hawaii) to study transport phenomena in ciliated surfaces. At the Wyss, she develops microfluidic devices and signal processing algorithms for exploring the mechanics and flow physics of dynamic tissues for applications in biomedical engineering, disease modeling, and biophysical research.

Location: Ronald Tutor Hall of Engineering (RTH) - 115

Audiences: Everyone Is Invited

Contact: Valerie Childress