Chonette Chair in Biomedical Technology and Professor of Biomedical Engineering
Education
- Doctoral Degree, Biomedical Engineering, University of Southern California
- Master's Degree, Electrical Engineering, Pennsylvania State University
- Bachelor's Degree, Electrical Engineering, University of Dayton
Biography
David Z. D'Argenio is Professor of Biomedical Engineering at the University of Southern and the inaugural holder of the Chonette Chair of Biomedical Technology. Professor D'Argenio has been a member of the Biomedical Engineering Faculty at USC since 1979. He is a Fellow of the American Institute for Engineering in Medicine and Biology, the American Association of Pharmaceutical Scientists and the International Society of Pharmacometrics. From 2003-2008 he served on the US FDA Advisory Committee for Pharmaceutical Science and Clinical Pharmacology. He has served as Chairman of the Department of Biomedical Engineering at USC from 1996-2003 and was the inaugural holder of the Dwight C. and Hildagarde E. Baum Chair of Biomedical Engineering. He also served as the Associate Dean for Academic Affairs in the School of Engineering at USC from 1993-1996 and as the Interim Director of the Alfred Mann Institute of BME at USC from 1998-1999. Professor D'Argenio has been a visiting scientist at St. Jude Children's Research Hospital, Memphis and at the Institute of Biomedical Engineering, CNR, Padova, Italy, as well as a visiting professor at the University of Halle-Wittenberg, Halle, Germany. His awards include: the Lewis B. Sheiner Award from International Society of Pharmacometrics in 2018; Gerhard Levy Distinguished Lectureship, Univ. of Buffalo, SUNY, 2016; the Mellon Mentoring Award, Univ. Southern California, 2010; the USC School of Engineering Service Award, 1992; the USC School of Engineering and TRW Excellence in Teaching Award in 1985. He was a co-founder on the International Society of Pharmcometrics (2010) and currently serves on its Board of Directors Nominating and Fellow Selection Committees. Professor D'Argenio has served as a consultant for numerous pharmaceutical and biotechnology companies, and was a founding member of the Board of Directors of Simulations Plus (NASDAQ: SLP), Inc from 1996-2016.
Research Summary
Since 1985 he has co-directed the Biomedical Modeling and Simulations Resource at USC, an NIH supported center that develops advanced modeling methods for studying biological systems. His research involves the development and application of methodologies for model informed discovery, development and precision use of medicines. Current areas of research include: quantitative systems pharmacology; drug induced neutropenia; modeling of monocloncal antibody pharmacokinetics; drug action on insulin/glucose regulation; hierarchal nonlinear modeling of drug effect heterogeneity; feedback control mechanisms in targeted therapy; pharmacokinetics/pharmacodynamics of antibody drug conjugates; construction of genetic networks from heterogeneous data sources; and software systems for modeling, simulation, design and analysis in pharmacometrics. These methods have been applied by Professor D'Argenio and his colleagues to numerous problems in drug discovery, development and therapy in the areas of oncology, infectious, metabolic disorders and autoimmune diseases. Professor D'Argenio has also led the development of the ADAPT software system for systems pharmacology and pharmacometrics. ADAPT facilitates the development and use new medicines, and is used by researchers and clinical scientists in universities, industry and government agencies.
Awards
- 2018 International Society of Pharmametrics Lewis B. Shiener Award
- 2016 Gerhard Levy Distinguished Lectureship, Univ. of Buffalo, SUNY
- 2014 Fellow, International Society of Pharmacometrics
- 2011 House Ear Institute Chair of the Board of DIrectors
- 2010 USC Melon Mentoring Award
- 2009 Fellow, American Association of Pharmaceutical Sciences
- 2005 Chonette Endowed Chair in Biomedical Technology
- 1999 Fellow, American Institute for Engineering in Medicine and Biology
- 1992 USC School of Engineering Service Award
- 1987 Mortarboard Outstanding University Faculty Member
- 1985 USC School of Engineering and TRW Excellence in Teaching Award
- 1983 Tau Beta Pi Teaching Award in Biomedical Engineering
- 1980 American Heart Association Fellow
- 1978 NIH Predoctoral Trainee Award
- 1972 University of Dayton Graduated magna cum laude
