Chonette Chair in Biomedical Technology and Professor of Biomedical Engineering
- Doctoral Degree, Biomedical Engineering, University of Southern California
- Master's Degree, Electrical Engineering, Pennsylvania State University
- Bachelor's Degree, Electrical Engineering, University of Dayton
David Z. D'Argenio is Professor of Biomedical Engineering at the University of Southern and holder of the Chonette Chair of Biomedical Technology. Professor D'Argenio has been a member of the Biomedical Engineering Faculty at USC since 1979. He is a Fellow of the American Institute for Engineering in Medicine and Biology, the American Association of Pharmaceutical Scientists and the International Society of Pharmacometrics. From 2003-2008 he served on the US FDA Advisory Committee for Pharmaceutical Science and Clinical Pharmacology. He has served as Chairman of the Department of Biomedical Engineering at USC from 1996-2003 and as the Associate Dean for Academic Affairs in the School of Engineering at USC from 1993-1996. He also served as the Interim Director of the Alfred Mann Institute of BME at USC from 1998-1999. He has been a visiting scientist at St. Jude Children's Research Hospital, Memphis and at the Institute of Biomedical Engineering, CNR, Padova, Italy, as well as a visiting professor at the University of Halle-Wittenberg, Halle, Germany.
Since 1985 he has co-directed the Biomedical Modeling and Simulations Resource at USC, an NIH supported center that develops advanced modeling methods for studying biological systems. His research involves the development and application of modeling methodologies for systems pharmacology, new medicine development and therapeutics. Current areas of research include: hierarchal nonlinear modeling of drug effect heterogeneity; feedback control mechanisms in targeted therapy, signaling models of FLT3 and CDK4/6 inhibitors in acute myeloid leukemia; pharmacokinetics/pharmacodynamics of antibody drug conjugates; construction of genetic networks from heterogeneous data sources; and software systems for modeling, simulation, design and analysis in pharmacometrics.
These methods have been applied by Professor D'Argenio and his colleagues to numerous problems in drug discovery, development and therapy in the areas of oncology, infectious diseases, metabolic disorders and immunology. Professor D'Argenio has also led the development of the ADAPT software system for systems pharmacology and pharmacometrics. ADAPT facilitates the development and use new medicines, and is used by researchers and clinical scientists in universities, industry and government agencies.
- 1972 University of Dayton Graduated magna cum laude
- 1978 NIH Predoctoral Trainee Award
- 1980 American Heart Association Fellow
- 1983 Tau Beta Pi Teaching Award in Biomedical Engineering
- 1985 USC School of Engineering and TRW Excellence in Teaching Award
- 1987 Mortarboard Outstanding University Faculty Member
- 1992 USC School of Engineering Service Award
- 1999 Fellow, American Institute for Engineering in Medicine and Biology
- 2005 Chonette Endowed Chair in Biomedical Technology
- 2009 Fellow, American Association of Pharmaceutical Sciences
- 2010 USC Melon Mentoring Award
- 2011 House Ear Institute Chair of the Board of DIrectors
- 2014 Fellow, International Society of Pharmacometrics
- 2016 Gerhard Levy Distinguished Lectureship, Univ. of Buffalo, SUNY