Associate Professor of Chemical Engineering and Materials Science and Gerontology
Education
- 2007, Doctoral Degree, California Institute of Technology
- 2004, Master's Degree, Chemical Engineering, California Institute of Technology
- 2001, Bachelor's Degree, Chemical Engineering and French, Washington University in St. Louis
Biography
Nick Graham is an Assistant Professor of Chemical Engineering at the University of Southern California. Dr. Graham received a BS in Chemical Engineering and French from Washington University in St. Louis in 2001. He received a PhD in Chemical Engineering from the California Institute of Technology in 2007 for research into the crosstalk between intercellular and intracellular signaling pathways under the guidance of Anand Asthagiri. He then did postdoctoral training at the University of California, Los Angeles, in the laboratory of Thomas Graeber, where he investigated the interactions between kinase signaling and tumor metabolism.
Research Summary
The Graham Lab focuses on using system biology approaches to understand and develop novel therapeutic approaches for cancer and other human diseases. We specialize in using mass spectrometry and other quantitative, high-content technologies to generate proteomic and metabolomic data from cancer cell lines, mouse models and human patient samples. Through integration of proteomic, metabolomic, genomic and phenotypic data, we aim to create data-driven computational models across multiple components and time scales. These models enable us to extract biological meaning from quantitative, complex data sets. Drawing on engineering, biology and statistics, we iterate between experimental and computational systems to test these predictive models. To enable discovery of new biological phenomena and translation of these systems biology models into the clinic, we are actively collaborating with chemists, physician scientists and oncologists.
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