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SUNMONTUEWEDTHUFRISAT
Events for March 14, 2025
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EiS Communications Hub - Tutoring for Engineering Ph.D. StudentsFri, Mar 14, 2025 @ 10:00 AM - 12:00 PM
Viterbi School of Engineering Student Affairs
Workshops & Infosessions
Viterbi Ph.D. students are invited to drop by the Hub for instruction on their writing and speaking tasks! All tutoring is one-on-one and conducted by Viterbi faculty.
Location: Ronald Tutor Hall of Engineering (RTH) - 222A
Audiences: Viterbi Ph.D. Students
Contact: Helen Choi
Event Link: https://sites.google.com/usc.edu/eishub/home
This event is open to all eligible individuals. USC Viterbi operates all of its activities consistent with the University's Notice of Non-Discrimination. Eligibility is not determined based on race, sex, ethnicity, sexual orientation, or any other prohibited factor. -
Alfred E.Mann Department of Biomedical Engineering - Seminar series
Fri, Mar 14, 2025 @ 11:00 AM - 12:00 PM
Alfred E. Mann Department of Biomedical Engineering
Conferences, Lectures, & Seminars
Speaker: Sheng Li, Ph. D., Associate Professor in the Department of Cancer Biology at the Keck School of Medicine, University of Southern California. She also serves as the Program Co-Leader of Epigenetic Regulation in Cancer at the USC NCI-designated Norris Comprehensive Cancer Ce
Talk Title: From Aging to Leukemia: Computational Epigenomics of Hematopoietic Stem Cell Fate
Abstract: Aging and epigenetic reprogramming are deeply intertwined in hematopoiesis and leukemogenesis. Our research investigates how genetic and epigenetic alterations shape hematopoietic stem cell (HSC) evolution, clonal expansion, and malignant transformation. First, using our next-generation and long-read sequencing pipelines, we demonstrated that somatic variations in DNA and histone methylation regulators disrupt the DNA methylome, promoting leukemogenesis. Second, we examined how aging alters HSC fate, clonal dynamics, and transcriptional states through genetic barcoding and single-cell RNA sequencing, revealing age-driven shifts in hematopoiesis via in vivo clonal tracing. We also explored how senolytic interventions reshape the aging hematopoietic transcriptome, potentially reversing age-related dysfunction. Finally, clonal hematopoiesis (CH) is an age-associated expansion of mutant hematopoietic stem cells, linked to leukemia and cardiovascular risk. We found that Tet2 deficiency mitigates epigenetic aging, preserving HSC function and assisting clonal expansion. By integrative mining of single-cell RNA sequencing and single-nucleus chromatin accessibility data, we investigated how Tet2 deficiency reprograms the aging epigenome and influences clonal fitness in CH. Together, these findings provide new insights into how aging and epigenetic dysregulation contribute to leukemogenesis and highlight potential therapeutic strategies for mitigating CH and malignant transformation in hematopoietic stem cells.
Biography: Sheng Li, Ph.D., is an Associate Professor in the Department of Cancer Biology at the Keck School of Medicine, University of Southern California. She also serves as the Program Co-Leader of Epigenetic Regulation in Cancer at the USC NCI-designated Norris Comprehensive Cancer Center. Dr. Li received her PhD in Computational Biology from Cornell University in 2014, where she focused on the computational transcriptomics and epigenomics of leukemia relapse. She then served as an Instructor of Bioinformatics at Weill Cornell Medicine in 2014. In 2016, Dr. Li joined the Jackson Laboratory for Genomic Medicine and was promoted to Associate Professor in 2022. In 2024, her lab moved to the USC Keck School of Medicine. The Li lab focuses on algorithm development and integrative mining of long-read, single-cell, and spatial multi-omics data to understand the impact of cell-to-cell variations – in epigenome and transcriptome – and aged microenvironment in driving cancer evolution. The Li Lab has been embedded in a network of NIH consortia, e.g., NCI-NIA jointly funded OncoAging Consortium, NIH Common Fund Cellular Senescence Network (SetNet) Consortium, and NHGRI funded The Encyclopedia of DNA Elements (ENCODE) Consortium. She co-chairs the Omics and Image-Mapping Working Group in SetNet Consortium since 2022. Dr. Li is a recipient of the NIH Maximizing Investigators' Research Award (2019), the American Association for Cancer Research's "NextGen Star" Award (2020), and the Leukemia and Lymphoma Society Scholar (2024).
Host: Peter Wang
Location: Ronald Tutor Hall of Engineering (RTH) - 109
Audiences: Everyone Is Invited
Contact: Carla Stanard
This event is open to all eligible individuals. USC Viterbi operates all of its activities consistent with the University's Notice of Non-Discrimination. Eligibility is not determined based on race, sex, ethnicity, sexual orientation, or any other prohibited factor. -
Alfred E.Mann Department of Biomedical Engineering - Seminar series
Fri, Mar 14, 2025 @ 11:00 AM - 12:00 PM
Alfred E. Mann Department of Biomedical Engineering
Conferences, Lectures, & Seminars
Speaker: Sheng Li, Ph.D., Associate Professor in the Department of Cancer Biology Program Co-Leader of Epigenetic Regulation in Cancer NCI-designated Norris Comprehensive Cancer Center Keck School of Medicine University of Southern California
Talk Title: From Aging to Leukemia: Computational Epigenomics of Hematopoietic Stem Cell Fate
Abstract: Aging and epigenetic reprogramming are deeply intertwined in hematopoiesis and leukemogenesis. Our research investigates how genetic and epigenetic alterations shape hematopoietic stem cell (HSC) evolution, clonal expansion, and malignant transformation. First, using our next-generation and long-read sequencing pipelines, we demonstrated that somatic variations in DNA and histone methylation regulators disrupt the DNA methylome, promoting leukemogenesis. Second, we examined how aging alters HSC fate, clonal dynamics, and transcriptional states through genetic barcoding and single-cell RNA sequencing, revealing age-driven shifts in hematopoiesis via in vivo clonal tracing. We also explored how senolytic interventions reshape the aging hematopoietic transcriptome, potentially reversing age-related dysfunction. Finally, clonal hematopoiesis (CH) is an age-associated expansion of mutant hematopoietic stem cells, linked to leukemia and cardiovascular risk. We found that Tet2 deficiency mitigates epigenetic aging, preserving HSC function and assisting clonal expansion. By integrative mining of single-cell RNA sequencing and single-nucleus chromatin accessibility data, we investigated how Tet2 deficiency reprograms the aging epigenome and influences clonal fitness in CH. Together, these findings provide new insights into how aging and epigenetic dysregulation contribute to leukemogenesis and highlight potential therapeutic strategies for mitigating CH and malignant transformation in hematopoietic stem cells.
Biography: Sheng Li, Ph.D., is an Associate Professor in the Department of Cancer Biology at the Keck School of Medicine, University of Southern California. She also serves as the Program Co-Leader of Epigenetic Regulation in Cancer at the USC NCI-designated Norris Comprehensive Cancer Center. Dr. Li received her PhD in Computational Biology from Cornell University in 2014, where she focused on the computational transcriptomics and epigenomics of leukemia relapse. She then served as an Instructor of Bioinformatics at Weill Cornell Medicine in 2014. In 2016, Dr. Li joined the Jackson Laboratory for Genomic Medicine and was promoted to Associate Professor in 2022. In 2024, her lab moved to the USC Keck School of Medicine. The Li lab focuses on algorithm development and integrative mining of long-read, single-cell, and spatial multi-omics data to understand the impact of cell-to-cell variations – in epigenome and transcriptome – and aged microenvironment in driving cancer evolution. The Li Lab has been embedded in a network of NIH consortia, e.g., NCI-NIA jointly funded OncoAging Consortium, NIH Common Fund Cellular Senescence Network (SetNet) Consortium, and NHGRI funded The Encyclopedia of DNA Elements (ENCODE) Consortium. She co-chairs the Omics and Image-Mapping Working Group in SetNet Consortium since 2022. Dr. Li is a recipient of the NIH Maximizing Investigators' Research Award (2019), the American Association for Cancer Research's "NextGen Star" Award (2020), and the Leukemia and Lymphoma Society Scholar (2024).
Host: Peter Wang
Location: Ronald Tutor Hall of Engineering (RTH) - 109
Audiences: Everyone Is Invited
Contact: Carla Stanard
This event is open to all eligible individuals. USC Viterbi operates all of its activities consistent with the University's Notice of Non-Discrimination. Eligibility is not determined based on race, sex, ethnicity, sexual orientation, or any other prohibited factor. -
CA DREAMS - Technical Seminar Series
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Fri, Mar 14, 2025 @ 12:00 PM - 01:00 PM
Information Sciences Institute
Conferences, Lectures, & Seminars
Speaker: Azita Emami, Professor, Caltech
Talk Title: Electronic-Photonic Co-Design for High-Speed Data Communication and Beyond
Abstract: Data centers continue to demand interconnect solutions with higher bandwidth densities and improved energy efficiency. Furthermore, applications such as chip-to-chip interconnects in switches, high-performance FPGAs and GPUs call for compact form-factors, high-volume production and low cost. Silicon Photonics (SiP)-based transceivers, when co-packaged with CMOS electronics, offer a promising avenue to meet these demands with speeds exceeding 100 Gb/s per wavelength. In this talk we focus on architectural and circuit-level techniques for both PICs and EICs to improve the energy-efficiency at high data rates. We will discuss how various types of optical modulators and optical architectures can be employed to achieve higher-order modulation schemes. We will first present a 100Gb/s 3D integrated Sip-CMOS PAM4 optical transmitter system. The photonic chip includes a push-pull segmented MZM structure using highly capacitive, yet optically efficient MOSCAP phase modulators. Co-design and optimum bandwidth enhancement techniques are employed to achieve high data rates and energy efficiency. Next a 100Gb/s DAC-less PAM-4 transmitter and a 200Gb/s QAM-16 transmitter in a multi-micron silicon photonics platform using binary-driven SiGe EAMs will be presented. In the second part of this talk, we will briefly show another example of co-designed electronics and photonics for sensing applications. We present a fully integrated fluorescence (FL) sensor in 65nm standard CMOS comprising on-chip bandpass optical filters, photodiodes (PDs), and processing circuitry. The metal/dielectric layers in CMOS are employed to implement low-loss cavity-type optical filters achieving a bandpass response at 600nm to 700nm range suitable to work with fluorescent proteins (FPs), which are the widely used bio-reporters for biomedical and environmental sensing.
Biography: Azita Emami is the Andrew and Peggy Cherng Professor of Electrical Engineering and Medical Engineering, and the Director of Center for Sensing to Intelligence (S2I) at Caltech. She received her M.S. and Ph.D. degrees in Electrical Engineering from Stanford University in 1999 and 2004 respectively, and her B.S. degree from Sharif University of Technology in 1996. From 2004 to 2006 she was with IBM T. J. Watson Research Center before joining Caltech in 2007. She served as the Executive Officer (Department Head) for Electrical Engineering from 2018 to 2024. Her current research interests include integrated circuits and systems, integrated photonics, high-speed data communication systems, wearable and implantable devices for neural recording, neural stimulation, sensing and drug delivery.
Host: Dr. Steve Crago
More Info: https://www.isi.edu/events/5480/electronic-photonic-co-design-for-high-speed-data-communication-and-beyond/
Webcast: https://usc.zoom.us/j/97017422125?pwd=Dbrt8MNMrmBV3xalKQJcAiNsggFJjJ.1&from=addonWebCast Link: https://usc.zoom.us/j/97017422125?pwd=Dbrt8MNMrmBV3xalKQJcAiNsggFJjJ.1&from=addon
Audiences: Everyone Is Invited
Contact: Amy Kasmir
Event Link: https://www.isi.edu/events/5480/electronic-photonic-co-design-for-high-speed-data-communication-and-beyond/
This event is open to all eligible individuals. USC Viterbi operates all of its activities consistent with the University's Notice of Non-Discrimination. Eligibility is not determined based on race, sex, ethnicity, sexual orientation, or any other prohibited factor. -
MHI/Physics Joint Seminar, Mark Eriksson, Friday, March 14th at 2pm in EEB 132 & Zoom
Fri, Mar 14, 2025 @ 02:00 PM - 03:30 PM
Ming Hsieh Department of Electrical and Computer Engineering
Conferences, Lectures, & Seminars
Speaker: Mark Eriksson, Wisconsin Quantum Institute and Department of Physics University of Wisconsin-Madison
Talk Title: Quantum computing using electron spins in silicon
Series: MHI Physics Joint Seminar Series
Abstract: Remarkably, the techniques used to make classical silicon CMOS devices can be used to make qubits with excellent performance. The operation of these devices, on the other hand - from the required temperatures to the number of electrons comprising a typical qubit - is very different from what is found in even the most advanced classical integrated circuits. In this talk I will present both a short historical overview of how quantum computing in silicon has developed, as well as the latest results from both our group at Wisconsin and from around the world. I will emphasize the role of integration, including 3D integration, which enables readout of qubits formed in a Si/SiGe by measuring the microwave transmission of a superconducting resonator on a separate substrate, flip-chip bonded to the first. And I will discuss very recent results demonstrating the remarkable properties of silicon quantum wells containing short wavelength oscillations in the concentration of added germanium atoms. Advances like these have, in just the last few years, demonstrated that a future quantum computing technology in silicon will likely integrate sophisticated techniques and knowledge cutting across many different academic departments, from electrical engineering to materials science, computer science, and physics - a feature that makes it an incredibly dynamic (and fun!) field of science and technology.
Biography: Mark A. Eriksson is the John Bardeen Professor of Physics and the Steenbock Professor of Physical Sciences at the University of Wisconsin-Madison. Prior to joining the University of Wisconsin in 1999 he received his Ph.D. from Harvard University in 1997 and was a postdoctoral member of technical staff at Bell Labs for two years from 1997-1999. Eriksson leads a team studying semiconductor-based quantum computing and focusing on the development of spin qubits in silicon/silicon-germanium gate-defined quantum dots. He also leads the Materials & Integration science and technology thrust area within the DOE-funded Q-NEXT center led by Argonne National Laboratory. Eriksson is a fellow of the American Physical Society and the American Association for the Advancement of Science.
Host: Quntao Zhuang, Eli Levinson-Falk, Jonathan Habif, Daniel Lidar, Kelly Luo,k Todd Brun, Tony Levi, Stephan Haas
More Info: https://usc.zoom.us/j/94210354265?pwd=SAYc7H3kA9JiRV7Ktrm2dgelJOCmbV.1
More Information: Mark Eriksson Flyer.pdf
Location: Hughes Aircraft Electrical Engineering Center (EEB) - 132
Audiences: Everyone Is Invited
Contact: Marilyn Poplawski
Event Link: https://usc.zoom.us/j/94210354265?pwd=SAYc7H3kA9JiRV7Ktrm2dgelJOCmbV.1
This event is open to all eligible individuals. USC Viterbi operates all of its activities consistent with the University's Notice of Non-Discrimination. Eligibility is not determined based on race, sex, ethnicity, sexual orientation, or any other prohibited factor.
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