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Nanoseconds, Megavolts, Picojoules, and Semiconductor Crystal Quantum Dots in the Intracellular Envi
Wed, Oct 06, 2004 @ 12:00 PM - 01:00 PM
Ming Hsieh Department of Electrical and Computer Engineering
University Calendar
P. Thomas Vernier, Ph.D.
Bioelectrical Engineer
University of Southern California
Megavolts, micrometers, picosecondsElectrical engineers play an important role in cross-disciplinary investigations of pulsed power applications in biomedicine at the University of Southern California, providing enabling technology for studies ranging from fundamental research in bioelectrical physics to
cancer diagnostics and therapeutics. We present an overview of this work, which includes:
- validation of biophysical models with experimental observations
(responses of molecules and membranes in living cells to nanosecond,
megavolt-per-meter pulsed electric fields);
- cellular signal transduction (nanoelectropulse-induced
intracellular calcium release);
- mechanisms of programmed cell death induction by ultra-short,
high-field electric pulses;
- internalization of fluorescent quantum dots for cell tagging and
tracking and for monitoring the intracellular environment;
- development of advanced pulse generators, catheter electrodes, and
other devices for remote delivery of nanoelectropulses to biological
systems;
- exploration of minimally invasive nanoelectropulse diagnostics and
therapeutics for malignancies, atherosclerosis, and other medical
conditions.P. Thomas Vernier, Engineering Manager of MOSIS at the University of Southern California Information Sciences Institute, received his Ph.D. in Electrical Engineering from USC in 2004. His research and industrial experience includes ultraviolet microscopy of psychrophilic yeasts, characterization of the temperature-sensitive host restriction of bacterial viruses, environmental gas monitoring, wide-band instrumentation data recording, and multi-project semiconductor wafer fabrication. He currently works on the responses of biological systems to nanosecond, megavolt-per-meter electric fields.Date: Wednesday, October 6, 2004
Place: Olin Hall 230 (OHE)
Time: 12:00 1:00
Refreshments will be served at 11:45
ALL First Year EE-EP Graduate Students are REQUIRED to ATTEND
Location: Olin Hall of Engineering (OHE) - 230
Audiences: Electrical Engineering Graduate Students
Contact: Robert Mena
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Football vs. California
Sat, Oct 09, 2004
USC Viterbi School of Engineering
University Calendar
Location: L.A. Coliseum
Audiences: Everyone Is Invited
Contact: Jason Dziegielewski
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Football vs. Arizona State
Sat, Oct 16, 2004
USC Viterbi School of Engineering
University Calendar
Location: L.A. Coliseum
Audiences: Everyone Is Invited
Contact: Jason Dziegielewski
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Q>100 million microresonators on silicon and applications
Wed, Oct 20, 2004 @ 12:00 PM - 01:00 PM
Ming Hsieh Department of Electrical and Computer Engineering
University Calendar
Kerry Vahala
Professor of Applied Physics &
Professor of Information Science and Technology
California Institute of TechnologyA novel laser processing method has been applied to create optical micro-resonators having Q factors as high as 500 million on silicon wafers. The combination of Ultra-high-Q and small mode volume opens up new applications for wafer based resonators. In this talk I will first review the processing and passive optical properties of these devices and then describe their application to demonstrate micro Raman and micro OPOs on a chip as well as rare-earth-doped lasers on silicon. Finally, I will describe some preliminary work underway that will apply these devices in cavity QED.Kerry Vahala is Ted and Ginger Jenkins Professor of Information Science and Technology and Professor of Applied Physics at Caltech. He also received his Ph. D. (85) in Applied Physics at Caltech. His research on micro-resonators has led to wafer-based devices operating in the Q regime above 100 million and has also provided low-loss methods for coupling directly to optical fiber. This performance combination has made possible microwatt-threshold nonlinear Raman and Parametric sources with quantum-limited differential efficiencies and is being actively pursued as a route to cavity QED on-a-chip systems. Vahala is a Fellow of the Optical Society of America and has served as topical editor for Photonics Technology Letters, the Journal of the Optical Society of America and the Journal of Semiconductor Science and Technology. He was program co-chair for CLEO 99 and General Chair for CLEO 2001. He was the first recipient of the Richard P. Feynman Hughes Fellowship and has also received both the Presidential Young Investigator and Office of Naval Research Young Investigator Awards. In addition, he has been recognized three times by the Student Association at Caltech for excellence in teaching and mentoring. Vahala is co-founder and Chairman of Xponent Photonics, located in Monrovia, CA.Date: Wednesday, October 20, 2004
Place: Olin Hall 230 (OHE)
Time: 12:00 1:00
Refreshments will be served at 11:45
ALL First Year EE-EP Graduate Students are REQUIRED to ATTENDLocation: Olin Hall of Engineering (OHE) - 230
Audiences: Everyone Is Invited
Contact: Robert Mena
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Football vs. Washington
Sat, Oct 23, 2004
USC Viterbi School of Engineering
University Calendar
Location: L.A. Coliseum
Audiences: Everyone Is Invited
Contact: Jason Dziegielewski
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Combining Molecular Recognition with MEMS
Wed, Oct 27, 2004 @ 12:00 PM - 01:00 PM
Ming Hsieh Department of Electrical and Computer Engineering
University Calendar
Prof. H.T. Soh
Program in Biomolecular Science and Engineering
Department of Mechanical & Environmental EngineeringThe capability to amplify, that is, to create multiple copies of a particular DNA through polymerase chain reaction (PCR) has caused a revolution in biotechnology. It has provided the means to detect genetic mutations and pathogenic organisms including viruses and bacteria. In this work, we propose to address an equally fundamental need the capability to sort, that is, to separate and isolate particular molecules, viruses, bacteria and other cells, from a large background of complex mixtures, at very high throughput, purity and efficiency.
In this work, we combine a novel technique of molecular and cellular labeling with Microsytems technology to create a disposable, massively parallel, rare-cell sorting system. The physical mechanism is based on dielectrophoresis (DEP) using inhomogeneous AC electrical fields. Our approach is truly unique in two aspects: first, we label the cells with specifically engineered DEP tags, so that the differences in dielectric constants provide a large force of separation. Second, we leverage the massive parallelism the hallmark of micro/nano fabrication technology to create a multi-stage array of sorting chambers to exponentially enhance the performance in throughput, purity, and recovery simultaneously.Hyongsok (Tom) Soh received his B.S. with distinction with a double major in Mechanical Engineering and Materials Science from Cornell University in 1992, and M.S. and Ph.D. degrees in Electrical Engineering from Stanford University in 1995 and 1999 respectively. He served as the technical manager of MEMS device research group at Bell Laboratories and Agere Systems before joining the University of California Santa Barbara in 2003. He has (co)authored over 30 technical papers, 10 patents and 1 book. He is a recipient of 2002 Top 100 Innovator award from MIT Technology Review, and 2004 Young Investigator Award from the Office of Naval Research.Date: Wednesday, October 27, 2004
Place: Olin Hall 230 (OHE)
Time: 12:00 1:00
Refreshments will be served at 11:45
ALL First Year EE-EP Graduate Students are REQUIRED to ATTEND
Location: Olin Hall of Engineering (OHE) - 230
Audiences: Everyone Is Invited
Contact: Robert Mena
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MESA College Day
Sat, Oct 30, 2004 @ 10:00 AM - 03:00 PM
Viterbi School of Engineering Student Affairs
University Calendar
Location: Mark Taper Hall Of Humanities (THH) -
Audiences: Everyone Is Invited
Contact: Larry Lim
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Football @ Washington State
Sat, Oct 30, 2004 @ 04:00 PM
USC Viterbi School of Engineering
University Calendar
Location: Pullman, Wash.
Audiences: Everyone Is Invited
Contact: Jason Dziegielewski