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Events for November 10, 2005

• Nov

  10

  Lyman Handy Colloquium

  Thu, Nov 10, 2005 @ 12:30 AM

  Mork Family Department of Chemical Engineering and Materials Science

  Conferences, Lectures, & Seminars

  
  

  Lyman L. Handy Colloquium
  Crystal Engineering for Product
  & Process DesignProfessor Michael F. Doherty
  Department of Chemical Engineering
  University of California, Santa BarbaraAbstractCrystalline organic solids are ubiquitous as either final products or as intermediates in the
  specialty chemical, pharmaceutical, and home & personal care industries. Virtually all small
  molecular weight drugs are isolated as crystalline materials, and over 90% of all pharmaceutical
  products are formulated in particulate, generally crystalline form. Crystalline chemical
  intermediates, such as adipic acid, are produced in large amounts to make polymers and specialty
  products. Skin creams and other personal care product formulations contain crystalline solids. In
  most cases the properties of the crystalline solid have a major impact on the functionality of the
  product as well as the design and operation of the manufacturing process.
  A novel method for modeling the shape evolution of 3-dimensional faceted crystals has been
  developed in which the normal distances to each face from an origin inside the crystal are
  represented by a system of ordinary differential equations. The model is initialized from an
  arbitrary initial seed shape and size, but known polymorph. The growth model for the crystal faces
  is based on surface integration kinetics as the rate determining step. The key variables on which
  the model depends are (1) properties of the solid state, such as unit cell, space group,
  intermolecular potentials, charge distribution, etc, and (2) surface free energy at the crystalsolution
  interface. At each time step, the entire family of possible discrete shape evolution events
  (e.g., vertices bifurcating into edges or faces, etc.) are exhaustively enumerated and investigated
  using a new set of simple testable conditions. The evolving crystal shape is then determined from
  the evolving set of normal distances and the corresponding crystallographic planes. The model has
  been successfully applied to a selection of complex molecular crystals of interest in pharmaceutical
  and specialty chemical products.
  In this presentation we discuss the interactions between crystal engineering and
  crystallization process & product design. We assess the current status of knowledge in this field and
  identify critical areas for future research and development.Thursday, November 10, 2005
  Seminar at 12:30 p.m. - OHE 122
  Refreshments served after the seminar in HED Lobby
  The Scientific Community is Cordially Invited

  Location: Olin Hall of Engineering (OHE) - 122

  Audiences: Everyone Is Invited

  Contact: Petra Pearce