Alfred E. Mann Department of Biomedical Engineering

Speaker: Michael Elowitz, Howard Hughes Medical Institute Investigator and Professor of Biology and Biological Engineering and Applied Physics at Caltech

Talk Title: Many to many protein networks: modules of multicellularity

Abstract: In multicellular organisms, many biological pathways exhibit a curious structure, involving sets of protein variants that bind or interact with one another in a many-to-many fashion. What functions do these seemingly complicated architectures provide. And can similar architectures be useful in synthetic biology. Here, I will discuss recent work in our lab that shows how many to many circuits can function as versatile computational devices, explore the roles these computations play in natural biological contexts, and show how many-to-many architectures can be used to design synthetic multicellular behaviors. 
 

Biography: Michael Elowitz is a Howard Hughes Medical Institute Investigator and Professor of Biology and Biological Engineering, and Applied Physics at Caltech. Dr. Elowitz's laboratory has introduced synthetic biology approaches to build and understand genetic circuits in living cells and tissues. As a graduate student with Stanislas Leibler, Elowitz developed the Repressilator, an artificial genetic clock that generates gene expression oscillations in individual E. coli cells. Since then, he has continued to design and build synthetic genetic circuits, bringing a “build to understand” approach to bacteria, yeast, and mammalian cells. He and his lab showed that gene expression is intrinsically stochastic, or ‘noisy’, and revealed how noise functions to enable probabilistic differentiation, time-based regulation, and other functions. Currently, Elowitz’s lab is bringing synthetic approaches to understand and program cell-cell communication, epigenetic memory and cell fate control, and to provide foundations for future therapeutic devices. His lab also co-develops the synthetic “MEMOIR” system that allows cells to record their own lineage histories. Elowitz received his PhD in Physics from Princeton University and did postdoctoral research at Rockefeller University. Honors include the HFSP Nakasone Award, MacArthur Fellowship, Presidential Early Career Award, Allen Distinguished Investigator Award, the American Academy of Arts and Sciences, and election to the National Academy of Sciences.

Host: Peter Wang

Location: Olin Hall of Engineering (OHE) - 100 B

Audiences: Everyone Is Invited

Contact: Carla Stanard