ECE Seminar: Dr. Guanghan Meng, "Capturing Life: Optical Microscopy for in vivo Deep Tissue Imaging at High Spatiotemporal Resolution"

Speaker: Dr. Guanghan Meng, Postdoctoral Scholar, Dept of EECS, UC Berkeley

Talk Title: Capturing Life: Optical Microscopy for in vivo Deep Tissue Imaging at High Spatiotemporal Resolution

Abstract: Optical microscopy has become an indispensable tool for non-invasive, high-resolution in vivo imaging of living organisms. Its capability to provide insights into real-time physiological and pathological processes within the body underscores its significance in bioscience and medicine. However, conventional optical microscopy methods have certain limitations. For instance, multiphoton fluorescence microscopy, the method of choice for in vivo imaging through scattering tissue such as the mammalian brains, delivers excellent resolution but falls short in speed for capturing rapid biological activities, such as blood flow dynamics. On the other hand, optical coherence tomography (OCT), a label-free deep-tissue imaging method, stands as a powerful instrument in contemporary optometry clinics, but its high cost limits its broad use, especially in lower-income communities. In this presentation, I will share my research on the development of high-speed multiphoton fluorescence microscopy and cost-effective OCT for brain and eye imaging, respectively, through the utilization of both optical engineering and computational methods.

Biography: Dr. Guanghan Meng, currently a postdoctoral scholar in the Department of Electrical Engineering and Computer Science at the University of California, Berkeley, focuses on advancing high-speed, high-resolution fluorescence, and label-free microscopy technologies for deep tissue imaging in vivo. Having earned her PhD from the same university, her doctoral research spanned the disciplines of Molecular and Cell Biology and Physics, primarily concentrating on enhancing two-photon fluorescence microscopy for mouse brain imaging. At present, she is working on computational label-free imaging with a specific interest in the human eye. Guanghan has been recognized with various best presentation awards at scientific conferences and is a recipient of the Berkeley Center for Innovation in Vision and Optics (CIVO) postdoctoral fellowship. Guanghan is also an invited lecturer at the 17th Edition of the Frontiers in Neurophotonics Summer School in Quebec City, Canada in 2024.

Host: Dr. Justin Haldar, jhaldar@usc.edu

Webcast: https://usc.zoom.us/j/96234786783?pwd=eXF0NnlvNEhPRHllS1NDUEFZWklSdz09

Location: Hughes Aircraft Electrical Engineering Center (EEB) - 248

WebCast Link: https://usc.zoom.us/j/96234786783?pwd=eXF0NnlvNEhPRHllS1NDUEFZWklSdz09

Audiences: Everyone Is Invited

Contact: Mayumi Thrasher