USC SleepHuB Special Seminar

Speaker: Jerone A. Dempsey, Ph.D., Professor at University of Wisconsin, Madison

Talk Title: Sleep Apnea Pathogenesis and Cardiovascular Consequences

Abstract: Sleep apnea prevalence continues to expand throughout the world, even within general, non-clinical populations. We will examine two aspects of the problem. First we will present evidence to support the concept that obstructive sleep apnea is as much attributable to neurochemical control of the stability of central respiratory motor output as it is to upper airway collapsibility. Secondly we will explore the complex, controversial question of the cardiovascular sequelae of sleep apnea through examination of evidence in both humans and animal models supporting the sustained “after-effects” of chronic , intermittent hypoxemia on both sympathetic, vasoconstrictor activity and on the vascular endothelium.

Biography: Jerry Dempsey, Ph.D., is a world-renowned respiratory physiologist, who is currently Professor Emeritus of Population Health Sciences, Physiology and Kinesiology, and previously, Director of the John Rankin Laboratory of Pulmonary Medicine, at University of Wisconsin (UW), Madison. He has made many invaluable contributions towards unraveling the biological mechanisms underlying a diverse set of problems in respiratory physiology. These include: the time-dependent sensitization of carotid chemoreceptors in acclimatization to altitude; the limits of the healthy and diseased human pulmonary system for gas transport, respiratory muscle function and ventilatory output during exercise; and the role of chemical and non-chemical influences on the regulation of breathing and autonomic cardiovascular function during sleep, particularly in the pathogenesis of sleep apnea and the effects of novel treatments on these factors. His research has been funded continuously for over 45 years with grants from NIH, AHA, VA, DOD and UW. Dr. Dempsey was past Editor-in-Chief of the Journal of Applied Physiology and Cross Talk Editor for the Journal of Physiology.

Host: BME Professor Michael Khoo, Co-Host CHLA Pulmonology & Sleep Medicine

More Info: https://us02web.zoom.us/j/363758496 (passcode: learn)

Location: Childrens Hospital (CHL) - Stauffer Conference Room A

Audiences: Everyone Is Invited

Contact: Carla Stanard

Event Link: https://us02web.zoom.us/j/363758496 (passcode: learn)