Alfred E.Mann Department of Biomedical Engineering - Seminar series

Speaker: Jeff Saucerman, Ph.D., Professor of Biomedical Engineering and Cardiovascular Medicine Vivian Pinn Scholar, School of Medicine University of Virginia

Talk Title: Fusing mechanistic networks and machine learning to understand inflammation-fibrosis coupling

Abstract: Inflammation and fibrosis are conserved phases of wound healing in the heart,skin, and other organs. Yet therapeutic attempts at manipulating inflammationand fibrosis have had limited success. In this talk, I will present ourcomputational and experimental systems biology research on cardiacinflammation and fibrosis. These studies include large scale computationalmodels of the intracellular signaling networks of multiple cardiac cell types,experimental drug screens, and new methods that fuse mechanistic andmachine-learning approaches to understand how these drugs work. Ourcomputational models are validated with new experiments in cells and mice.

Biography: Dr. Jeff Saucerman is a Professor of Biomedical Engineering and Professor ofCardiovascular Medicine at the University of Virginia. He leads a research group in cardiacsystems biology, focused on identifying and controlling the molecular networks involved inheart disease. He received a B.S. in Engineering Science from Pennsylvania StateUniversity, Ph.D. in Bioengineering from the University of California San Diego, andcompleted a postdoctoral fellowship with Dr. Donald Bers at Loyola University Chicago. Dr.Saucerman has received a number of awards including an NSF CAREER Award, Fellow ofthe American Heart Association and American Institute of Medical and BiologicalEngineering, the Dean’s Excellence in Teaching Award, BME Mentoring Award, and theVivian Pinn Scholar Award.

Host: Stacey Finley

Location: 101

Audiences: Everyone Is Invited

Contact: Carla Stanard