Alfred E.Mann Department of Biomedical Engineering - Seminar series

Speaker: Gen-Sheng Feng, PHD., Professor Department of Pathology, School of Medicine Department of Molecular Biology, School of Biological Sciences University of California, San Diego

Talk Title: Mechanistic dissection and immunotherapy of liver cancer

Abstract: I will describe our research program that aims at elucidating the paradoxical anti-oncogenic effects of classical oncoproteins in hepatocellular cancer, which was initiated by the discovery of an SH2-containing tyrosine phosphatase Shp2 (originally called Syp) while a postdoc with the late Tony Pawson. In particular, I will discuss most recent data that unveil how Shp2 promotes signaling through the RTK-Ras-Erk pathway. This work has led to the most recent discovery of a new type of vesicle, intercellsome, in cell-cell communication to offset intracellular proliferative signal deficit. I will also discuss mechanisms of liver cancer initiation and progression driven by the dynamic interactions between tumor cells and the microenvironment. By deciphering multi-faceted roles of the immune ecosystem, we aim to develop new strategies for combinatorial liver cancer immunotherapy through coordinated activation of innate and adaptive immune cells.

Biography: Gen-Sheng Feng is Professor of Pathology and Molecular Biology at the University of California, San Diego. He has been approved for promotion to Distinguished Professor at UCSD (effective on July 1, 2025). Dr. Feng got BSc degree in Biology from Hangzhou University, and PhD degree from Indiana University Bloomington. He received postdoctoral training at the University of Toronto, Canada. Dr. Feng has published 193 peer-reviewed research papers, reviews and book chapters. Dr. Feng has served on the editorial boards of MCB, JBC, Hepatology, and J Hepatology. He is a Fellow of American Association for the Advancement of Science (AAAS). Dr. Feng was the President for the Association of Chinese Americans in Cancer Research (ACACR, 2022-2024) and the President-elect for the Society of Chinese Bio scientists in America (SCBA).

Host: Peter Yingxiao Wang- Chair of Alfred E. Mann Department of Biomedical Engineering

Location: Ronald Tutor Hall of Engineering (RTH) - 109

Audiences: Everyone Is Invited

Contact: Carla Stanard

This event is open to all eligible individuals. USC Viterbi operates all of its activities consistent with the University's Notice of Non-Discrimination. Eligibility is not determined based on race, sex, ethnicity, sexual orientation, or any other prohibited factor.

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