Engineering Living Tissue Substitutes: A Design and Manufacturing Perspective

DANIEL J. EPSTEIN DEPARTMENT OF INDUSTRIAL AND SYSTEMS ENGINEERING - ISE 650 SEMINAR"Engineering Living Tissue Substitutes: A Design and Manufacturing Perspective"Binil Starly, Ph.D.Assistant Professor, School of Industrial Engineering, University of Oklahoma, NormanABSTRACT: The multidisciplinary field of tissue engineering brings together the disciplines of life sciences and engineering which seeks to produce man made substitutes for diseased tissue/organ replacement. To aid engineers in their quest to biomimic tissue and organ morphology, Computer-Aided Tissue Engineering presents itself as a systematic engineering methodology which applies enabling computer-aided technologies for representing, modeling, designing, and manufacturing engineered tissue structures. A central design component in tissue engineering is the use of scaffolds/constructs that provides a structural framework for target cells to attach, grow and proliferate to provide the required tissue function. Scaffolds with designed interior pore architecture, defined porosity and an interconnected predetermined nutrition network has been the most favored design approach. To create these scaffolds/constructs, Solid Freeform Fabrication technologies have enabled precise control over architecture, biomaterial distribution and fabrication of living cellular constructs. The presentation will address 1) BioCAD modeling techniques for patient specific constructs; 2) Design of macro and micro-architecture of tissue substitutes; 3) Biofabrication technologies; 5) Future research directions to the advancement of biomodeling and tissue manufacturing.FRIDAY, SEPTEMBER 28, 2007, 11:00 AM – 12:00 PM, ANDRUS GERONTOLOGY (GER) 309BIOGRAPHY: Binil Starly is currently appointed as an Assistant Professor in the School of Industrial Engineering at the University of Oklahoma, Norman. Binil received his B.Tech. degree in Mechanical Engineering from the University of Kerala, India, and his Ph.D. in Mechanical Engineering from Drexel University, Philadelphia, PA in 2006. Binil has published over 14 journal publications and have 2 patents pending in the field of scaffold design and fabrication for tissue engineering applications. He has received awards as part of his graduate studies that include the Graduate Research Award, Outstanding Service Award and the '2006 Most Likely to Enhance Drexel's Reputation' award. He is currently the faculty advisor of the Laboratory for Engineering Living Tissue Systems engaged in the design, real time quantitative analysis and fabrication of three dimensional (3D) tissue constructs for applications in tissue engineering, regenerative medicine and drug screening studies. His research and education interests include Computer-Aided Tissue Engineering, Biomechanical Engineering, Design and Manufacturing, CAD/CAE/CAM, Solid Freeform Fabrication, Tissue-on-chip systems and Construct Embedded Sensors.

Location: Ethel Percy Andrus Gerontology Center (GER) - 309

Audiences: Everyone Is Invited

Contact: Georgia Lum