Fri, Jan 21, 2011 @ 11:30 AM - 01:00 PM
Alfred E. Mann Department of Biomedical Engineering
Conferences, Lectures, & Seminars
Speaker: Robert Getzenberg, Ph.D., Professor and Director of the James Buchanan Brady Urological Institute,
Talk Title: Cancer cell stress response and the evolution of resistance â the connection between the physical microenvironment and nuclear structure
Abstract: The ability of cancer cells to evolve resistance is one of the major limitations in the efficacy of cancer therapies today. This enhanced evolutionary capability appears to have influenced how the cancer cell responds to physical microenvironmental changes. These microenvironmental influences appear to be act, at least in part, through nuclear structural elements and DNA organization, which have been shown to be involved in the development of resistance. Additionally, the disordered nature of protein structure appears to be central to cancer cell responses to stresses. Modification of the physical microenvironment may enhance the efficacy of currently used therapeutic agents as well as open new avenues for the development of novel types of approaches.
Location: Harkness Auditorium, CSC 250, IGM Building
For additional information contact: 323-442-3849 or 323-442-2596
Biography: Robert Getzenberg, Ph.D.
Professor and Director of the James Buchanan Brady Urological Institute,
Johns Hopkins University School of Medicine
Host: Dr. Parag Mallick, Center for Applied Molecular Medicine
Audiences: Everyone Is Invited
Contact: Yvonne Suarez