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Events for the 1st week of October
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Fall 2018 Joint CSC USC/CommNetS-MHI Seminar Series
Mon, Oct 01, 2018 @ 02:00 PM - 03:00 PM
Ming Hsieh Department of Electrical and Computer Engineering
Conferences, Lectures, & Seminars
Speaker: Vanessa Jonsson, City of Hope Beckman Research Institute
Talk Title: Adaptive Clinical Trial Design to Address Acquired Resistance and Therapeutic Failure
Abstract: One of the challenges facing immunotherapy as a durable therapeutic approach in a variety of metastatic cancers is the development of acquired resistance and subsequent therapeutic failure. Widespread clinical applicability of immunotherapy to solid tumors depends on the understanding of response and resistance mechanisms that are mediated by evolving interactions between the immune system and cancer cells. These dynamic interactions are increasingly being identified through longitudinal molecular analysis and immunological profiling and combine to produce an evolving measure of a patient cancer-immune status. However, cancer immune dynamics have yet to be formally quantified and studied as an evolutionary process in the context of immunotherapy clinical trials. To address this, we propose a method to integrate high dimensional, heterogeneous, longitudinal patient-derived cancer and immunological clinical data sets to identify cancer immune dynamics as well as a control theoretic method to preemptively address the onset of resistance through the prediction and synthesis of actionable immunotherapy combination strategies. We apply these methods to genomic and immunological data collected from a patient with recurrent multifocal glioblastoma that elicited a complete response and eventually recurred while enrolled in City of Hope's ongoing IL13R 2-targeting chimeric antigen (CAR) T cell trial for patients with recurrent glioblastoma. We show that dynamic treatment strategies are necessary for the control of tumors with high antigen heterogeneity and propose this as a framework by which to assess the effectiveness of adaptive clinical trial design and patient stratification for combination immunotherapy trials.
Biography: Vanessa Jonsson is an assistant research professor in the and Department of Hematology and Hematopoietic Cell Transplantation and leader of the Computational Immuno-Oncology group in the T Cell Immunotherapy Program at City of Hope. Her research program in computational biology focusses on the integration, mathematical modeling and analysis of large-scale, longitudinal genomic, transcriptomic and immunological data from clinical studies to inform and address the mechanisms of immune-resistant cancer progression. In 2015, Vanessa completed her PhD at Caltech, where she was advised by Richard Murray and David Baltimore. She is a principal investigator on a Parker Institute for Cancer Immunotherapy award to model the evolution of cancer immunity during immunotherapy trials and co-investigator on a California Institute of Regenerative Medicine (CIRM) award to study response and resistance in a phase I CAR T cell trial targeting malignant glioma. She is the recipient of the NIH and NCI career development award in clinical oncology (K12), with a focus on immuno-oncology.
Host: Mihailo Jovanovic
More Info: http://csc.usc.edu/seminars/2018Fall/jonsson.html
More Information: 18.10.01_Vanessa Jonsson CSCUSC Seminar.pdf
Location: Hughes Aircraft Electrical Engineering Center (EEB) - 132
Audiences: Everyone Is Invited
Contact: Brienne Moore
Event Link: http://csc.usc.edu/seminars/2018Fall/jonsson.html
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On the Role of Interaction in Future Mobility Systems, from Vehicle-Centric to System-Wide Control
Wed, Oct 03, 2018 @ 12:00 PM - 01:00 PM
Ming Hsieh Department of Electrical and Computer Engineering
Conferences, Lectures, & Seminars
Speaker: Dr. Marco Pavone, Aeronautics & Astronautics, Stanford University
Talk Title: On the Role of Interaction in Future Mobility Systems, from Vehicle-Centric to System-Wide Control
Series: Center for Cyber-Physical Systems and Internet of Things
Abstract: In this talk I will discuss my work on self-driving vehicles, with an emphasis on accounting for interactions with external counterparts at both the vehicle- and system-levels. Specifically, I will first discuss a decision-making framework that enables a self-driving vehicle to proactively interact with humans to infer their intents, and to use such information for safe and efficient driving. I will then turn the discussion to the operational and economic aspects of autonomous mobility-on-demand (AMoD) systems, with an emphasis on the interaction between AMoD and other infrastructures, such as the electric power and public transit networks.
Biography: Dr. Marco Pavone is an Assistant Professor of Aeronautics and Astronautics at Stanford University, where he is the Director of the Autonomous Systems Laboratory and Co-Director of the Center for Automotive Research at Stanford. Before joining Stanford, he was a Research Technologist within the Robotics Section at the NASA Jet Propulsion Laboratory. He received a Ph.D. degree in Aeronautics and Astronautics from the Massachusetts Institute of Technology in 2010. His main research interests are in the development of methodologies for the analysis, design, and control of autonomous systems, with an emphasis on self-driving cars, autonomous aerospace vehicles, and future mobility systems. He is a recipient of a Presidential Early Career Award for Scientists and Engineers, an ONR YIP Award, an NSF CAREER Award, a NASA Early Career Faculty Award, a Hellman Faculty Scholar Award, and was named NASA NIAC Fellow in 2011. He was identified by the American Society for Engineering Education (ASEE) as one of America's 20 most highly promising investigators under the age of 40. His work has been recognized with best paper nominations or awards at the Field and Service Robotics Conference, at the Robotics: Science and Systems Conference, and at NASA symposia. He is currently serving as an Associate Editor for the IEEE Control Systems Magazine.
Host: Professor Paul Bogdan
Location: Hughes Aircraft Electrical Engineering Center (EEB) - 132
Audiences: Everyone Is Invited
Contact: Talyia White
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CENG Seminar Series
Thu, Oct 04, 2018 @ 02:00 PM - 03:00 PM
Ming Hsieh Department of Electrical and Computer Engineering
Conferences, Lectures, & Seminars
Speaker: Yu Hua, Huazhong University of Science and Technology
Talk Title: Encrypted Non-volatile Main Memory Systems
Abstract: Non-volatile memory (NVM) technologies are considered as promising candidates of the next-generation main memory. However, the non-volatility of NVMs leads to new security vulnerabilities. Memory encryption can be employed to mitigate the security vulnerabilities, but it increases the number of bits written to NVMs due to the diffusion property and thereby aggravates the NVM wear-out induced by writes. To address these security and endurance challenges, we propose DeWrite, a secure and deduplication-aware scheme to enhance the performance and endurance of encrypted NVMs based on a new in-line deduplication technique and the synergistic integrations of deduplication and memory encryption. Specifically, it performs low-latency in-line deduplication to exploit the abundant cache-line-level duplications leveraging the intrinsic read/write asymmetry of NVMs and light-weight hashing. It also opportunistically parallelizes the operations of deduplication and encryption and allows them to co-locate the metadata for high efficiency. DeWrite was implemented on the gem5 with NVMain.
Biography: Dr. Yu Hua is a professor in Huazhong University of Science and Technology. He was Postdoc Research Associate in McGill University in 2009, and Postdoc Research Fellow in University of Nebraska-Lincoln in 2010-2011. He obtained his B.E and Ph.D degrees from Wuhan University respectively in 2001 and 2005. His research interests include file systems, cloud storage systems, non-volatile memory, big data analytics, etc. He publishes multiple papers in conferences and journals, including OSDI, MICRO, FAST, USENIX ATC, ACM SoCC, SC, HPDC, etc. He serves for multiple international conferences, including USENIX ATC, ASPLOS (ERC), SC, ACM SoCC, RTSS, ICDCS, ICCD, INFOCOM, IPDPS, etc. He is the distinguished member of CCF, senior member of ACM and IEEE, and the member of USENIX. He has been appointed as the Distinguished Speaker of ACM and CCF. His homepage is at: https://csyhua.github.io
Host: Xuehai Qian, xuehai.qian@usc.edu
More Information: 18.10.04_Yu Hua_CENG Seminar.pdf
Location: Hughes Aircraft Electrical Engineering Center (EEB) - 248
Audiences: Everyone Is Invited
Contact: Brienne Moore
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CCI presents Blockfinity's "Bringing Cities on to the Blockchain - Los Angeles"
Thu, Oct 04, 2018 @ 07:00 PM - 09:00 PM
Ming Hsieh Department of Electrical and Computer Engineering
Receptions & Special Events
Blockchain is a fast-growing technology with the intent to decentralize bureaucratic processes, create transparent transactions between multiple parties, and optimize enormous databases. The applications are endless when it comes to government, and municipalities, but our goal is to bring the community together to discuss theory, implementation, and case studies of how cities may work with Blockchain.
Let's imagine the changes in social, economic and environmental by ridding of bureaucracy in city infrastructure such as piles of papers, giant traffic jams, documentation errors and double transactions. Join our discussion to understand which cities around the world are implementing blockchain and how, what can be improved, and how would this help us here in Los Angeles.
Please RSVP here:
Bringing Cities on to the Blockchain - Los AngelesLocation: Hughes Aircraft Electrical Engineering Center (EEB) - 132
Audiences: Everyone Is Invited
Contact: Brienne Moore
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Farewell to Servers: Hardware, Software, and Network Approaches towards Datacenter Resource Disaggregation
Fri, Oct 05, 2018 @ 10:00 AM - 11:00 AM
Ming Hsieh Department of Electrical and Computer Engineering
Conferences, Lectures, & Seminars
Speaker: Yiying Zhang, Purdue University
Talk Title: Farewell to Servers: Hardware, Software, and Network Approaches towards Datacenter Resource Disaggregation
Abstract: Datacenters have been using a "monolithic" server model for decades, where each server has a motherboard that hosts a set of hardware devices such as processors and memory chips. This monolithic architecture is easy to deploy but cannot fully support the growing hardware heterogeneity in datacenters or provide hardware elasticity, failure isolation, and efficient resource utilization. Going forward, we have to rethink the decade-long server-centric model.
Our answer is to break the monolithic server model into distributed, network-attached hardware components that can each manage its own resources and can fail independently. For the past three years, my lab has been working on such datacenter "resource disaggregation" at system software, networking, and hardware levels. In this talk, I will discuss our various efforts in building a disaggregated datacenter (or "DC-3.0"). Specifically, I will focus on two systems: LegoOS, a new distributed, disseminated OS designed for datacenter resource disaggregation (OSDI'18), and LITE, a Local Indirection TiEr in kernel to virtualize native RDMA into a flexible, high-level, easy-to-use abstraction (SOSP'17).
Biography: Yiying Zhang is an assistant professor in the School of Electrical and Computer Engineering at Purdue University. Her research interests span operating systems, distributed systems, datacenter networking, and computer architecture, with a focus on building software, hardware, network systems for next-generation datacenters. Her lab is pioneering in the field of datacenter resource disaggregation and is among the few groups in the world that builds new OSes and full-stack, cross-layer systems. She has published at and served on the program committees of top systems conferences such as SOSP, OSDI, and ASPLOS, and her work has attracted various industry and academia attentions. Yiying received her Ph.D. from the Department of Computer Sciences at the University of Wisconsin-Madison and worked as a postdoctoral scholar at the University of California, San Diego before joining Purdue.
Host: Xuehai Qian, xuehai.qian@usc.edu
More Information: 18.10.05_Yiying Zhang .pdf
Location: Hughes Aircraft Electrical Engineering Center (EEB) - 248
Audiences: Everyone Is Invited
Contact: Brienne Moore
