Events for the 1st week of April
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USC SleepHuB Special Seminar
Wed, Apr 03, 2024 @ 04:00 PM - 05:30 PM
Alfred E. Mann Department of Biomedical Engineering
Conferences, Lectures, & Seminars
Speaker: Jerone A. Dempsey, Ph.D., Professor at University of Wisconsin, Madison
Talk Title: Sleep Apnea Pathogenesis and Cardiovascular Consequences
Abstract: Sleep apnea prevalence continues to expand throughout the world, even within general, non-clinical populations. We will examine two aspects of the problem. First we will present evidence to support the concept that obstructive sleep apnea is as much attributable to neurochemical control of the stability of central respiratory motor output as it is to upper airway collapsibility. Secondly we will explore the complex, controversial question of the cardiovascular sequelae of sleep apnea through examination of evidence in both humans and animal models supporting the sustained “after-effects” of chronic , intermittent hypoxemia on both sympathetic, vasoconstrictor activity and on the vascular endothelium.
Biography: Jerry Dempsey, Ph.D., is a world-renowned respiratory physiologist, who is currently Professor Emeritus of Population Health Sciences, Physiology and Kinesiology, and previously, Director of the John Rankin Laboratory of Pulmonary Medicine, at University of Wisconsin (UW), Madison. He has made many invaluable contributions towards unraveling the biological mechanisms underlying a diverse set of problems in respiratory physiology. These include: the time-dependent sensitization of carotid chemoreceptors in acclimatization to altitude; the limits of the healthy and diseased human pulmonary system for gas transport, respiratory muscle function and ventilatory output during exercise; and the role of chemical and non-chemical influences on the regulation of breathing and autonomic cardiovascular function during sleep, particularly in the pathogenesis of sleep apnea and the effects of novel treatments on these factors. His research has been funded continuously for over 45 years with grants from NIH, AHA, VA, DOD and UW. Dr. Dempsey was past Editor-in-Chief of the Journal of Applied Physiology and Cross Talk Editor for the Journal of Physiology.
Host: BME Professor Michael Khoo, Co-Host CHLA Pulmonology & Sleep Medicine
More Info: https://us02web.zoom.us/j/363758496 (passcode: learn)
Location: Childrens Hospital (CHL) - Stauffer Conference Room A
Audiences: Everyone Is Invited
Contact: Carla Stanard
Event Link: https://us02web.zoom.us/j/363758496 (passcode: learn)
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Alfred E. Mann Department of Biomedical Engineering
Fri, Apr 05, 2024 @ 11:00 AM - 12:00 PM
Alfred E. Mann Department of Biomedical Engineering
Conferences, Lectures, & Seminars
Speaker: Huimin Zhao, Ph.D., Professor of Chemical and Biomedical Engineering, Chemistry, Biophysics and computational Biology, University of Illinois, IL
Talk Title: Synthetic Biology 2.0: the Dawn of a New Era
Abstract: Synthetic biology aims to design novel or improved biological systems using engineering principles, which has broad applications in medical, chemical, food, and agricultural industries. Thanks to the rapid advances in DNA sequencing and synthesis, genome editing, artificial intelligence/machine learning (AI/ML), and laboratory automation in the past two decades, synthetic biology has entered a new phase of exponential growth. In this talk, I will highlight our recent work on the development of a self-driving biofoundry and AI/ML tools for synthetic biology applications and next-generation genome editing tools. Examples include but are not limited to: (1) BioAutomata: a self-driving biofoundry for pathway engineering and protein engineering, (2) ECNet: an AI tool for enzyme engineering, (3) CLEAN: an AI tool for enzyme function prediction, (4) FAST-RiPP & FAST-NPS: an automated and scalable platform for rapid discovery of bioactive natural products, and (5) zCRISPR-Cas12: a new tool for precise gene knock-in and highly efficient multiplex genome editing.
Biography: Dr. Huimin Zhao is the Steven L. Miller Chair of chemical and biomolecular engineering at the University of Illinois at Urbana-Champaign (UIUC), director of NSF AI Institute for Molecule Synthesis (moleculemaker.org), and Editor in Chief of ACS Synthetic Biology. He received his B.S. degree in Biology from the University of Science and Technology of China in 1992 and his Ph.D. degree in Chemistry from the California Institute of Technology in 1998 under the guidance of Nobel Laureate Dr. Frances Arnold. Prior to joining UIUC in 2000, he was a project leader at the Industrial Biotechnology Laboratory of the Dow Chemical Company. He was promoted to full professor in 2008. Dr. Zhao has authored and co-authored over 430 research articles and over 30 issued and pending patent applications. In addition, he has given over 490 plenary, keynote, or invited lectures. Thirty-seven (37) of his former graduate students and postdocs became professors or principal investigators around the world. Dr. Zhao received numerous research and teaching awards and honors such as AIChE Daniel I.C. Wang Award, AIChE FP&B Division Award, ECI Enzyme Engineering Award, ACS Marvin Johnson Award, and SIMB Charles Thom Award. His primary research interests are in the development and applications of synthetic biology, machine learning, and laboratory automation tools to address society’s most daunting challenges in health, energy, and sustainability.
Host: Peter Wang
Location: Corwin D. Denney Research Center (DRB) - DRB 146
Audiences: Everyone Is Invited
Contact: Carla Stanard